Fatigue

woman having trouble getting out of bed

Is Chronic Fatigue Syndrome a gut issue?

Chronic fatigue syndrome (CFS) is a very frightening and complicated disorder. Defined as severe exhaustion that can’t be relieved by rest, this condition has frustrated modern medicine for a long time.

Also known as myalgic encephalomyelitis (ME/CFS), this disease has no real triggers or underlying conditions, and diagnosing it requires a lot of time and testing. Although anyone can have CFS, women are far more likely to suffer from it than men, most commonly in their middle years.

Its symptoms run the gamut, from extreme fatigue lasting more than a day and unexplained joint or muscle pain to enlarged lymph nodes, headaches, poor sleep and even irritable bowel syndrome (IBS).

While CFS is a condition with very few connections, research teams at Columbia and Cornell Universities have found important markers that link it to the human gut.

83 percent accurate

The discovery that connects chronic fatigue syndrome to the human gut was a welcome confirmation to Cornell researchers that its origins were definitely not psychological.

“Our work demonstrates that the gut bacterial microbiome in ME/CFS patients isn’t normal, perhaps leading to gastrointestinal and inflammatory symptoms in victims of the disease,” says Dr. Maureen Hanson, senior author of the study, according to a press release. “Furthermore, our detection of a biological abnormality provides further evidence against the ridiculous concept that the disease is psychological in origin.”

For the record, the Cornell study compared blood and stool samples from 48 CFS patients to 39 health controls. The links to a gut health connection were obvious.

Chronic fatigue patients had less gut bacteria diversity and their blood samples showed signs of inflammation linked to leaky gut. Stool samples also found markers for ulcerative colitis and Crohn’s disease, even more serious gut problems.

Moreover, scientists were able to detect which patients were battling CFS based on microbiome testing with 83 percent accuracy.

Gut imbalances affect severity

Mirroring the Cornell findings, Columbia researchers also found bacterial imbalances – too much of some bacterial species including Faecalibacterium – in the fecal samples of the 50 chronic fatigue syndrome patients they examined (versus an equal number of healthy ones), according to the study appearing in Microbiome.

These imbalances varied depending on whether CFS patients were also suffering from IBS or not (21 of the 50 patients did have IBS). Also, depending on which bacteria imbalance chronic fatigue syndrome patients had and the metabolic pathways affected, the severity of their symptoms differed too.

“Individuals with ME/CFS have a distinct mix of gut bacteria and related metabolic disturbances that may influence the severity of their disease,” says Columbia researcher Dorottya Nagy-Szakal, according to a press release.

Probiotic success

Despite all of the attention paid by Columbia and Cornell researchers, a few scientists already had an eye on the intersection of gut health and chronic fatigue syndrome.

In fact, a systemic review of studies appearing very recently in Beneficial Microbes cited studies that showed how using probiotics may be effective in treating CFS and fibromyalgia.

(Both studies cited in this review used proprietary strains of Lactobacillus and Bifidobacterium, the two building blocks of EndoMune Advanced Probiotic.)

Based on these results, it seems more likely probiotics could become part of a more comprehensive treatment plan for chronic fatigue syndrome. 

“If we have a better idea of what is going on with these gut microbes and patients, maybe clinicians could consider changing diets using prebiotics such as dietary fibers or probiotics to treat the disease,” says Ludovic Giloteaux, a researcher in the Department of Molecular Biology and Genetics at Cornell University.

a woman taking a nap on her couch

How Gut Health Affects Your Sleep, Your Brain

You’ve probably heard a lot in the news about sleep hygiene, the behaviors and practices that you can do to protect and enhance your slumber time, and why that’s so important for your health.

However, one of those benefits – a healthier brain – can be at risk if you aren’t sleeping well, and changes in your gut may be the tell-tale sign, according to a study appearing in Sleep Medicine.

Over the course of the study, researchers monitored the sleep habits and gut health of 37 healthy patients (ages 50-85) who provided fecal samples and completed assessments for sleep, mental acuity, diet and overall health.

The interesting findings here were positive connections with two specific phylum of bacteria in the gut: Verrucomicrobia and Lentisphaerae.

Higher amounts of both bacteria were associated to positive results – better sleep quality and good cognitive flexibility (your brain’s ability to switch between two different concepts or consider many concepts at the same time).

It certainly makes sense that sleep and our brains can be affected by these disruptions, given the growing amount of research that has shown how our gut bacteria follow a 24-hour circadian, wake/sleep schedule.

This inter-dependence between the gut and your circadian rhythms could also make your body more vulnerable to changes that promote obesity. Not to mention, we’ve also discussed how your circadian rhythms can get disrupted more easily due to jet lag, particularly when you travel long distances.

A growing number of experts believe gut health is linked to healthy sleep. “Scientists investigating the relationship between sleep and the microbiome are finding that the microbial ecosystem may affect sleep and sleep-related physiological functions in a number of different ways: shifting circadian rhythms, altering the body’s sleep-wake cycle, affecting hormones that regulate sleep and wakefulness,” says Dr. Michael Breus, a fellow at the American Academy of Sleep Medicine, according to The Guardian.

As research continues on the gut-sleep connection, Dr. Breus suggests taking a probiotic along with a prebiotic in the meantime to feed your gut.

Separate from ensuring you follow good sleep hygiene and eat the right foods, keeping your gut and brain in alignment is as simple as taking a high-quality probiotic, like EndoMune Advanced Probiotic, that contains 10 strains of beneficial bacteria and Fructooligosaccharides (FOS), a prebiotic that feeds the microbes in your gut and may help you sleep better too.

Your Gut Bacteria Have a 24-Hour Routine

Messing up your body’s circadian rhythms — the behavioral, mental and physical changes that follow a 24-hour cycle — can have a huge effect on your health and gut.

Merely traveling on an airplane across multiple time zones can trigger jet lag, a temporary sleep problem when your body’s internal rhythms and biological clock are out of sync.

Apparently, your gut bacteria have a circadian schedule too, and a pair of studies shows how they affect your health for better and worse.

Following a schedule

Research by scientists at the Weizmann Institute of Science on mice in a study appearing in Cell demonstrated how gut bacteria follow a schedule, adapting to changes in light and dark, metabolic fluctuations and even the timing of our meals, says Dr. Eran Segel.

In fact, your microbiome moves around within the gut and are exposed to different species and varying numbers of species over the course of a 24-hour day.

Moreover, those changes brought on by circadian rhythms affect not only the physiology of the body but tissues and organs like the liver. Those rhythms can even govern how your body may metabolize and detoxify a drug as basic as acetaminophen.

Scientists also learned how the circadian rhythms of the bodies of little mice (and perhaps humans too) are very dependent on the workings of the microbiome. Surprisingly, genes that show no signs of circadian rhythms take over when these microbial rhythms are disrupted too.

These findings were observed when researchers gave mice antibiotics that removed much of their gut bacteria and even when their feeding times were changed.

Circadian rhythms and obesity

This inter-dependence between the gut and the body’s circadian rhythms could play a role behind the scenes in promoting the accumulation of body fat that leads to obesity, according to a recent study conducted at the University of Texas Southwestern and published in the journal, Science.

Based on tests that compared the health of germ-free, conventionally raised and genetically modified mice, scientists learned how the microbiome controls fat uptake and storage by “hacking into” and altering the functions of the circadian clocks within cells that line the gut.

They identified the mechanism by which gut bacteria regulate the composition of body fat and use a chemical (circadian transcription factor NFIL3) to establish a critical molecular link between the microbiota, circadian clock and metabolism, says Dr. Lora Hooper, lead author of the study, according to a press release.

So how does the microbiota hack into the lining of the gut?

A body’s circadian clock senses those day and night cycles, which are linked closely to feeding times, and transmits that information to the gut to turn on and off the metabolism (the uptake of lipids) when necessary.

More specifically, the circadian rhythms of the gut control the expression of NFIL3 and the production of lipids that are governed by this chemical in the intestinal lining.

“So what you have is a really fascinating system where two signals from the environment come in – the microbiome and the day-night changes in light – and converge on the gut lining to regulate how much lipid you take up from your diet and store as fat,” says Dr. Hooper.

How does this affect you?

Our go-go-GO! lifestyles create all sorts of havoc with our sleep schedules and often distract us from eating healthy meals on a timely basis, creating an environment for all sorts of health problems down the line.

Eating a balanced diet and getting the right amount of sleep your body needs every night really matters. And, we’ve learned in these studies, so does the health of the human gut, especially if you do a lot of traveling or work a crazy schedule that mixes daytime and nighttime hours.

That’s why it’s so important to give the health of your gut an added boost by taking a multi-species probiotic, like EndoMune Advanced Probiotic, that features 10 proven and protective strains of beneficial bacteria and a prebiotic that feeds the good bugs and may improve your sleep too!

Can excessive exercise promote leaky gut?

The benefits from regular exercise — from reducing your risks to catastrophic conditions like cancer, type 2 diabetes and cardiovascular disease to improving your brain — are many and varied. In fact, a very popular Lancet study argued the lack of regular exercise could be as deadly to your health as smoking.

But, what happens when you take exercise to the opposite extreme? Overdoing anything often reverses much of the benefits you might’ve achieved in moderation, and exercise is no exception.

Based on a 2015 study published in the Journal of the American College of Cardiology, people who exercised more than four hours a week had virtually the same risk of dying as sedentary folks who rarely exercised.

A pair of very recent scientific reports have also tied excessive exercise to serious health problems that may promote leaky gut, a disorder in which a breakdown in the intestinal wall allows unintended substances — undigested food, toxic waste products, bacteria and viruses — to seep through the intestinal barrier and into the bloodstream.

Extreme exercise may harm your gut after 2 hours

Exercising for two hours at 60 percent of the maximum volume of oxygen an athlete can use (VO2 max) along with stress felt from excess heat pushed patients into an unhealthy state, based on a review of studies featured in Alimentary Pharmacology and Therapeutics.

How does that happen? If a patient’s gut loses a lot of blood during exercise, medical experts speculate the resulting inflammation can leave its protective lining damaged. In this vulnerable state, an ideal environment is created for leaky gut.

This review also determined that low to moderate exercise may be beneficial for patients suffering from irritable bowel syndrome (IBS) or inflammatory bowel disease (IBD).

Lengthy military training may harm the gut too

Prolonged exercise was a trigger for leaky gut in a second study appearing in the American Journal of Physiology — Gastrointestinal and Liver Physiology.

In this study, military scientists from Norway, the U.S. Army and the Geneva Foundation as well as the Frederick National Laboratory for Cancer Research tracked the health of 73 Norwegian Army soldiers training in cross country skiing for four days. During that time, soldiers skied 31 miles while carrying 99-pound backpacks.

Researchers collected blood and fecal samples before and after the exercise. Before giving urine samples on the first and third days of training, soldiers drank a mix of water and sucralose and mannitol (an artificial sugar and a sugar alcohol, respectively) to detect signs of leaky gut.

By the end of the training period, the collective gut health of these soldiers as well as the composition of substances in blood and stool samples taken from them changed significantly and for worse. The excretion of sucralose rose greatly too, indicating an increase in leaky gut.

Multi-species probiotics do make an impact

Despite the good probiotics do, some scientists believe they may not do much to protect gut permeability. However, a 2012 report from the Journal of the International Society of Sports Nutrition that tracked the health of 22 trained athletes taking multi-species probiotics proved otherwise.

The key takeaway: The production of zonulin — an inflammatory protein that regulates leakiness in the gut — decreased slightly from levels slightly above normal to normal ranges, then dropped significantly after 14 weeks of supplementation with multi-species probiotics.

There are times when the leakiness triggered by zonulin protects your body in healthy ways, experts say, when you eat foods contaminated with harmful bacteria. When that happens, zonulin reacts by triggering diarrhea to get rid of the bad bugs.

Not only is taking a probiotic with multiple strains of beneficial bacteria like EndoMune Advanced Probiotic an ideal way to shorten the duration of diarrhea, this non-drug treatment gives your body a much needed boost to its natural defenses and may offer some protection from leaky gut too.

Could your gut be training your body to yo-yo diet?

Losing weight isn’t easy. It takes a lot of consistent effort in many areas — exercise, food choices, portion control, sleep, self-esteem are just a few — to do it the safe and right way.

Sadly, life often gets in the way and not every weight loss effort goes as planned. Sometimes, this can lead to weight cycling, better known as yo-yo dieting.

Although there’s no general consensus among medical experts whether repeatedly losing and regaining weight is bad, there are health consequences associated with yo-yo dieting, like coronary issues, extra stress and a slower metabolism.

A recent series of tests by a team of Israeli researchers pinpointed a potential cause for yo-yo dieting in a study appearing in Nature: A gut microbiome that changes when weight is lost, then exposed to high-fat foods again.

 

The experiments

As scientists studied mice, they discovered an important constant with yo-yo dieting: After one cycle of gaining and losing weight, every bodily system in their test subjects reverted to normal except for their microbiomes. For some six months after their weight loss, mice retained an “obese” microbiome.

“This persistent microbiome accelerated the regaining of weight when the mice were put back on a high-calorie diet or ate regular food in excessive amounts,” said lead researcher Dr. Eran Elinav of the Weizman Institute of Science in a press release.

No surprise, when researchers transplanted gut bacteria from obese mice into germ-free mice, they began to gain weight too when fed high-fat foods.

It was only when scientists bombarded obese mice with broad-spectrum antibiotics or gave them fecal samples from mice that had never been obese that the cycle stopped.

Those treatments may work for mice, but for humans, antibiotics have been a known enemy of gut health for a very long time and fecal transplants have unintended consequences that may do more harm than good.

However, scientists identified a pair of flavonoids, a diverse family of natural chemicals found in nearly all fruits and vegetables, that were in short supply among obese mice that would improve fat-burning.

When mice were fed flavonoids in their drinking water, their little bodies readjusted and didn’t experience accelerated weight gains, even when fed high-calorie diets.

 

Targeting the gut

Whether extra flavonoids will work on the guts of humans to prevent yo-yo weight gains is anyone’s guess. However, there’s one critical aspect of gut health that the Israeli study didn’t investigate.

Microbial diversity in the gut plays a vital role in protecting humans from all kinds of health issues, not to mention obesity. Unfortunately, our go-go-go lifestyles can make it difficult to eat at the right times, get enough exercise or follow a consistent sleep schedule.

That’s when taking a quality probiotic made with multiple strains of beneficial bacteria like EndoMune Advanced Probiotic can make a big impact in protecting your health.

Garlic works with your gut to protect your cardio health

Allium sativum, better known as garlic, is a versatile and flavorful member of the onion family.

Not only has garlic been used to bring flavor to foods for thousands of years, this vegetable has a long history in natural medicine. The Greek physician, Hippocrates was known to prescribe it for fatigue, respiratory problems and poor digestion, according to the Journal of Nutrition.

Hippocrates’ counterparts in the Middle East and Asia used garlic to treat serious ailments, such as bronchitis and hypertension, as well as less troublesome problems like flatulence and colic.

Today, garlic has garnered even more interest, based on an array of medical studies over the past 15 years, naming it as a therapeutic treatment for fighting colds, improving bone health and reducing hypertension.

New research in the Journal of Functional Foods has discovered a new way for garlic to improve your cardiovascular health, with the indirect help of your healthy gut and a good diet.

The problem is the production of Trimethylamine N-oxide, TMAO, a metabolite produced by the liver after gut bacteria digests animal protein. This metabolite contributes to heart disease.

In a study conducted on four groups of mice, researchers discovered that test animals that were fed carnitine (a nutrient contained in red meat, dairy products, avocados and peanut butter) for six weeks produced “a remarkable increase” in plasma TMAO levels, compared to a control group that was given no carnitine.

When garlic is crushed or chopped, the enzyme allinase is released which speeds up the formation of allicin, according to the Linus Pauling Institute at Oregon State University. The average garlic clove weighs up to 4 grams and can produce as much as 4,500 micrograms of allicin.

However, when the test subjects were given allicin, a sulfur-based compound in garlic, along with the carnitine, their TMAO levels dropped significantly.

Moreover, the TMAO levels of the group that consumed allicin were as low as those found in the control group who were given no carnitine at all.

This discovery gives medicine a natural and less harmful weapon to fight TMAO. In the past, physicians have treated this condition with antibiotics, which are known to disrupt the balance of bacteria in the gut.

Another way to improve your cardiovascular health from a gut perspective: boost your intake of dietary fiber along with taking a probiotic, ideally a product containing multiple strains of beneficial bacteria like EndoMune Advanced Probiotic.

Consuming beneficial foods like garlic, along with a probiotic like EndoMune, are simple ways to improve your cardio health.

Jet lag may affect your gut health, increase obesity risks

Jet lag — a temporary sleep problem created when your body’s natural circadian rhythms are out of whack — is a common occurrence for people who regularly fly long distances and multiple time zones for business or pleasure (or do regular shift work).

You may be surprised to learn jet lag, long associated with symptoms including fatigue and sleeplessness, has become such a health problem that it’s now defined by experts as a disorder.

No wonder, considering a recent study from the Weizman Institute of Science (Israel) that compared the gut microbiota of mice at different times during a 24-hour cycle concluded jet lag may also affect your gut health and trigger more serious problems including obesity, cardiovascular disease, cancer and diabetes.

These differences between healthy and jet-lagged gut bacteria were most pronounced when comparing fecal samples from healthy mice and genetically engineered mice with disabled circadian clocks kept in normal 12-hour cycles of light and dark.

During the light phase, the healthy gut microbiomes of mice functioned normally, detoxifying their environments and building flagella that help microbes move, according to the journal Science. Bacteria were more active during the dark phase, digesting nutrients, growing and repairing DNA. During a 24-hour day, some 60 percent of bacterial types in normal mice fluctuated.

In genetically modified mice, however, their gut bacteria didn’t experience the same fluctuations of growth or activity, leading scientists to conclude an animal’s biological/circadian clock has a direct effect on gut health.

Another very noticeable and health-harming difference between both sets of mice was their eating habits. Genetically modified mice ate almost all of the time while normal mice ate only at night (when they’re very active). Additionally, the modified mice gained weight and exhibited other health complications related to diabetes (insulin resistance), according to Science.

Interestingly, this same shift in the composition of gut bacteria to unhealthy extremes was also observed during part of the study in which researchers compared the fecal bacteria of two humans who lived on a normal schedule to another pair who had travelled from America to Israel and endured jet lag.

The good news: Although the fecal samples of human subjects who were jet-lagged experienced an uptick in unhealthy bacteria linked to patients with diabetes and obesity, their microbiome returned to normal after their bodies adjusted to the distant time zone.

“Our inner microbial rhythm represents a new therapeutic target that may be exploited in future studies to normalize the microbiota in people whose lifestyle involves frequent alterations in sleep patterns, hopefully to reduce or even prevent their risk of developing obesity and its complications,” said Dr. Eran Elinav of the Weizmann Institute’s Immunology Department in a press release.

Dr. Elinav also believes populations harmed by jet lag or shift work may benefit from probiotics or other antimicrobial therapies that “may reduce or even prevent their risk of developing obesity and its complications.”

Just another of the many reasons travelers and swing-shift workers benefit from taking a multi-strain probiotic, like EndoMune Advanced Probiotic or EndoMune Advanced Junior (for kids) that contains multiple strains of beneficial bacteria to boost your immunity by maintaining a healthy balance of good gut bacteria.

kids clapping together

Avoid the Norovirus on your Cruise

You’ve spent a lot of time and effort saving up for that once-in-a lifetime vacation: a leisurely cruise taking you and your loved ones across the ocean to some exotic locale.

Then, you get “that” call from one of your fellow travelers warning you about the Royal Caribbean Explorer of the Seas ship disaster last winter during which some 650 passengers and crew members were sickened by a gastrointestinal illness.

As you dig deeper on the Internet, you learn that the Centers for Disease Control and Prevention (CDC) identified 53 separate outbreaks of gastrointestinal illness between 2010-13 and start to wonder if the CNN headline “Are cruise ships floating petri dishes?” isn’t true.

The likely target of this massive illness: norovirus, an infection that causes the sudden onset of severe diarrhea, abdominal pain and vomiting, and a leading cause of acute gastroenteritis, according to the Mayo Clinic.

Typically, symptoms can last up to three days and most people recover on their own. But, in some instances, the norovirus may hit older adults, infants and those with underlying diseases harder, necessitating medical attention.

(Cruise ships aren’t the only places where the norovirus infections can spread. Schools, hospitals and nursing homes can be breeding grounds, too.)

A worldwide problem

A recent report in The Lancet Infectious Diseases spelled out the problems with the norovirus on a worldwide scale, featuring data from 48 countries on some 187,000 cases reported from 1990-2014.

You may be very surprised to learn the frequency of norovirus was slightly more common in developed countries (20 percent) than in undeveloped nations (14-19 percent).

Avoid the norovirus on your cruise by taking a probiotic“Norovirus spreads from person to person and through contaminated food and water and contact with contaminated surfaces,” said Dr. Benjamin Lopman, the lead author of this study who works in the Division of Viral Diseases at the CDC in Atlanta.

“The virus is contagious that as few as 18 viral particles may be enough to infect a healthy person, while more than a billion viruses can be found in a single gram of an infected person’s stool.

“Our findings show that norovirus infection contributes substantially to the global burden of acute gastroenteritis, causing both severe and mild cases and across all age groups,” Dr. Lopman concluded.

Unfortunately, the study authors believe their conclusions justify the development of a norovirus vaccine. However, there’s really no need for one more vaccine, as long as you follow the six ways to avoid traveler’s diarrhea outlined in a recent blog post.

Research has concluded taking a probiotic like EndoMune Advanced Probiotic or EndoMune Advanced Junior for kids before a long-distance vacation can boost your family’s immunities naturally and help them avoid norovirus infections altogether.

 

10 safe, natural ways to stop allergies

With the warmth of spring comes the nagging irritation of allergies for 50 million Americans, according to the American College of Allergy, Asthma & Immunology.

Unfortunately, spring allergies could stretch long into the summer depending on where you live, and factors like the priming effect, climate change and hygiene hypothesis could influence their severity. Complicating the treatment of allergies further are the unexpected side effects that arise from relying too often on antihistamines.

National Asthma and Allergy Awareness month has come around at the ideal time to remind you of the many ways you can keep these pesky allergens from harming your health without drugs. What follows are 10 completely safe and effective ways to do just that.

Keep it clean

1. To prevent allergens from following you into your home, wash your body every day and change your clothes. And, don’t forget to leave your shoes at the front door too.

2. A 2013 study in the Annals of Internal Medicine found acupuncture, a natural treatment that brings pain relief to millions, may also be effective for allergy sufferers. Patients who received acupuncture showed greater improvements and didn’t use their antihistamines as often.

3. Cutting back on fast foods and eating at least three servings of fruit per day may reduce symptoms. Consuming fast food at least three times a week elevated the risks of severe asthma by up to 39 percent among young children and teens.

4. Checking local weather reports every day for pollen counts is crucial. You can also access online resources like The Weather Channel’s Allergies page or the National Allergy Bureau to get personalized forecasts for your area.

5. Closing your windows and running your air conditioner longer will add to your energy costs, but doing both will reduce pollen from swimming into your home.

Protect your bedroom from allergy invaders

6. You spend more time in your bedroom than any other place in your home, thus it’s important to wash all bed sheets, pillow cases and blankets in water heated to at least 130 degrees Fahrenheit every week, according to the Mayo Clinic.

7. Invest a little money by having professional cleaners do a deep cleaning of your entire home, including baseboards, window shades, tile floors and ceilings. And, don’t forget to change your home’s air filters promptly and wash your washing machines to remove extra surprises.

8. Although washing pets can be problematic — your cat will hate you for even considering it — create allergy-free zones in your home to restrict their access, according to the Humane Society of the United States.

9. Working to alleviate the stressors that flood your head may reduce the number of flare-ups with more intense symptoms, according to a recent Ohio State University study.

10. Because your body is under non-stop attack from allergens, taking a probiotic may help, as this recent PLOS ONE study showed in boosting the immunity of patients to hay fever.

With its multiple strains of beneficial bacteria, EndoMune Advanced Probiotic boosts your immune system naturally and safely while maintaining your good gut health.

Probiotics can improve hypertension

Study after study shows that probiotics help treat gastrointestinal issues including IBS, diarrhea, gas and constipation. However, the benefits aren’t confined to digestive health.

Recent studies are also proving that probiotics can improve hypertension, more commonly known as high blood pressure. Primarily caused by environmental factors such as salt intake, minimal exercise, weight gain and high cholesterol due to bad diet, high blood pressure is a major risk factor for stroke, heart attacks and heart failure.

The International Journal of Molecular Science published a review on various studies conducted on how probiotics improved hypertension, particularly the effects on cholesterol and diabetes. Among their conclusions, researchers proved that probiotics could reduce the amount of cholesterol, thus decreasing the chance of high blood pressure. Additionally, probiotics provide a safe alternative treatment to drugs or hormone therapy, with milder or no known side effects.

Probiotics not only treat digestion problems, but they also help lower your risk for hypertension. Add a daily probiotic like EndoMune Advanced Probiotic to your diet to improve your chances for a healthier life.

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