Mental Health

Mental Health issues, according to an increasingly number of studies examining the link between digestive health and our brains, may improve by restoring our gut health.

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The Probiotic Treatment For Anxiety

Experiencing anxiety is more common than you think.

Think about the last time…

  • You went to the hospital for a medical test.
  • You gave a talk in front of a group of people, including some you didn’t know.
  • You had to make a decision about a problem with no clear-cut solutions.

Any one of those situations are potentially nerve-wracking, but they tend to pass pretty quickly.

But, if you’re frequently avoiding situations that could create excessive worries, you may be dealing with an anxiety disorder, and that may be a real problem.

Many people — including health providers — turn to antidepressants like fluoxetine (Prozac) or escitalopram (Lexapro) or benzodiazepines like diazepam (Valium) or alprazolam (Xanax) to alleviate anxiety.

However, taking drugs (especially benzodiazepines) may create even more health challenges down the road.

Did you know taking better care of your gut health may be just as beneficial in treating anxiety?

The gut health solution

As you know, there’s plenty of evidence supporting the gut-brain axis, the connection linking your intestines, brain and emotions.

A new report by Chinese researchers, recently published in the journal General Psychiatry, reviewed a batch of studies, finding 21 studies that examined boosting gut health as a means to treat anxiety.

The success rate was excellent. Eleven of the 21 studies discovered improvements in anxiety symptoms by treating a patient’s gut health.

Interestingly, the results were split nearly down the middle with five studies finding success with probiotics and six studies treating patients through non-probiotic means such dietary interventions.

Of course, there were limitations, as most of the patients participating in these students were having problems with an array of health issues. Among the six studies that did examine gut health interventions to treat anxiety, four showed positive results.

Listed among the non-probiotic interventions was the use of short-chain fructo-oligosaccharides (FOS), a natural prebiotic made from plant sugars and non-digestible starches. Additionally, FOS is one of the key ingredients in EndoMune Advanced Probiotic.

It’s important to remember prebiotics feed the good guys in your gut, but really do a lot more good when they’re part of an effective probiotic like EndoMune.

Drug-free treatments for anxiety

There are many things you can do treat anxiety that don’t require taking a drug:

All of these things have one important thing in common: Not only do they improve your overall health, they do wonders for your gut.

In addition to working on these healthier habits, be sure to take an effective probiotic like EndoMune, with multiple strains of beneficial bacteria, plus a prebiotic.

Illustration of probiotics at a cellular level.

The Multi-Species Advantage For Your Brain and Mood

The human gut is one very diverse sector of the human body.

More than 1,000 unique species of gut bacteria have been identified by medical investigators so far. That doesn’t include 2,000 more species recently discovered in populations of people living in Asia, Africa and South America.

What we do know (for the moment): Experts believe about 150-170 species live in the human gut at any time.

So, when we talk about the value of treating health problems like constipation, C. diff infections and even colon cancer, probiotics that contain multiple species of beneficial bacteria have been proven to do much more good than single-species products or even “probiotic” foods.

The gut-brain axis difference

The very same can be said for your gut-brain axis, the vital connection that links your brain, emotions and intestines, according to recent research appearing in the medical journal, Frontiers in Psychiatry.

For this study, researchers at the University of Verona (Italy) tracked the progress of 38 healthy volunteers (ages 18-35) who took either a placebo or multi-species probiotic including Lactobacillus rhamnosus, Lactobacillus plantarum and Bifidobacterium longum for six weeks.

(This trio is part of the 10 species of beneficial bacteria contained in every bottle of EndoMune Advanced Probiotic.)

Scientists monitored the mood, mental health and sleep quality of patients before the study began, then in three-week intervals during and after the study concluded.

The group who took probiotics reported significant improvements in fatigue, mood and anger, better acceptance (a marker of decreased depression) and enhanced sleep quality.

In fact, scientists were surprised to find benefits from taking multi-species probiotics lingered at least three weeks after the test subjects stopped taking them.

Those positive results for multi-strain probiotics aren’t surprising at all, given that the gut produces neurotransmitter chemicals like serotonin (governing your mood) and gamma-aminobutyric acid (GABA) (controlling anxiety and fear).

Getting good sleep matters too

A healthy gut helps you get the right amount of sleep too. Not only does it promote better sleep, good gut health eases disruptions in your body’s circadian rhythms — governing your 24-hour biological clock — particularly when jet lag can be a factor due to traveling across multiple time zones in short periods of time.

Another gut-healthy way to promote restful sleep: Be sure you’re eating enough prebiotics, the natural, non-digestible carbohydrates/plant fiber contained in whole foods like almonds, jicama, artichokes, onions, leeks, apples and bananas.

If you’re not getting enough whole foods, that’s just one more important reason to take a daily probiotic like Endomune, that features fructo-oligosaccharides (FOS), a natural prebiotic made from plant sugars.

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The Gut-Brain Link to Depression and Obesity

It wasn’t long ago that conventional medicine debated the existence of the gut-brain axis, the connection that links your emotions, intestines and brain.

The medical community couldn’t dispute it for long, however, given that about 90 percent of serotonin, a chemical that sends messages from one side of the brain to the other, is produced in the human gut.

Obesity and diabetes are serious conditions that harm many parts of your health, including your gut. (Remember, gut health problems could be a warning sign of type 1 diabetes?)

Eating a high-fat diet, a direct contributor to obesity and diabetes, creates greater emotional problems and direct shifts in the makeup of bacteria in the gut too, according to findings from the Joslin Research Center (affiliated with Harvard Medical School).

In their work with mice, Joslin researchers had long studied the damage done by diabetes, obesity and other metabolic health problems in their work with mice fed high-fat diets.

One variable stood out in their previous research: Obese mice that had been fed high-fat diets showed far more signs of emotional problems (depression, anxiety and obsessive behaviors) than animals fed healthier diets.

For their newest study, researchers took a different approach by giving mice behavioral tests commonly used to screen drugs for depression and anxiety. They learned mice that were fed high-fat diets experienced greater amounts of depression and anxiety.

However, when scientists took steps to change the gut health makeup of obese mice by giving them antibiotics their emotional health improved.

Taking that gut bacteria shift one step further, Joslin research also discovered the gut microbiomes of obese mice triggered emotional problems when they were transplanted in germ-free mice. And other germ-free mice that received gut bacteria from obese mice given antibiotics showed no signs of emotional problems either.

Where the gut-brain link really came into play was when researchers examined parts of the brain that govern metabolism and emotions, according to Dr. C. Ronald Kahn, Chief Academic Officer who leads the Section on Integrative Physiology and Metabolism at Joslin.

Like other tissues, these areas of the brain became insulin-resistant in test animals fed high-fat diets and this resistance was mediated partly by their microbiomes, Dr. Kahn said.

The Joslin team also found alterations in the gut health of mice were linked to the production of some chemicals that send signals across the brain too.

Now, scientists are studying specific populations of bacteria involved in the gut-brain axis that may govern this process, with an eye on creating healthier metabolic profiles in the brain.

Interestingly, Dr. Kahn points out the problems of using antibiotics as “blunt tools that change many bacteria in very dramatic ways.”

“Going forward, we want to get a more sophisticated understanding about which bacteria contribute to insulin resistance in the brain and other tissues. If we could modify those bacteria, either by putting in more beneficial bacteria or reducing the number of harmful bacteria, that might be a way to see improved behavior.”

Fortunately, there’s a growing body of evidence that shows probiotics like EndoMune Advance Probiotic may be a safe and proven tool for treating behavioral issues among mice and humans and provide some extra help to fight obesity too.

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A Healthy Gut May Protect Your Liver

We’ve talked a lot about how the gut is so hard-wired to the body that it governs many aspects of your health behind the scenes, from the inner workings of your brain to getting a healthy night’s sleep.

Your gut microbiome may also play an important role in spotting early warning signs of nonalcoholic fatty liver disease (NAFLD), the most common form of chronic liver disease harming patients who build up too much fat in their liver, according to research in Nature Medicine.

Not only does NAFLD affect people in their middle years (especially those with a higher risk of metabolic syndrome), it is the most common form of liver disease found in children, according to the American Liver Foundation.

The most common problem with NAFLD, according to the Mayo Clinic, is cirrhosis, usually in response to inflammation due to nonalcoholic steatohepatitis (a syndrome that promotes liver damage not associated with alcoholism but is indistinguishable from it).

Over time, some 20 percent of patients who are diagnosed with nonalcoholic steatohepatitis will fight cirrhosis.

The reason this discovery by European researchers led by Imperial College London is so very important: NAFLD has few external signs, apart from fatigue, abdominal pain and an enlarged liver. But, sometimes, there’s no signs at all.

Unless blood work or an ultrasound is recommended by a physician, this disease may not be detected until damage to the liver is significant.

European researchers led by Imperial College London found this gut health link by comparing biological data from 100 obese women with fatty livers (including fecal, blood and urine samples and liver biopsies) to those taken from healthy patients.

Scientists involved in the research identified a compound produced by gut bacteria — phenylacetic acid (PAA) — that breaks down amino acids for food and could be used down the road by doctors to screen patients in blood tests for NAFLD.

Not only do high PAA levels signal more fat accumulating in the liver, subtle drops in genetic gut health diversity begin to occur.

As NAFLD becomes more advanced, the number of genes encoded by gut bacteria lessen, thus the composition and diversity of the gut drops too.

That’s not surprising, considering metabolic syndrome — the cluster of conditions fueled by obesity and high-fat diets that boost your risk of cardiovascular issues like stroke and heart disease — harms your gut by creating problems that alter your gut bacteria and produce inflammation in your intestine.

More studies are needed to determine how and why PAA may be linked to NAFLD and its relation to gut bacteria imbalances.

In the meantime, if you’ve been fighting a losing battle with metabolic syndrome, experiencing trouble losing weight and are concerned about the damage being done to your gut, you’re in luck.

EndoMune Metabolic Rescue and its unique blend of Bifidobacterium lactis and the prebiotic XOS work in tandem to restore the balance of bacteria in your gut and give your body the boost it needs to promote weight loss in an effective and healthy way.

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Gut Health May Play a Role in PTSD

For a long time, many people have associated posttraumatic stress disorder (PTSD) — a condition that develops in some who have experienced a dangerous, shocking or frightening event — with soldiers and police officers who deal with life and death situations on a daily basis.

Some experts who understand it intimately, however, believe PTSD is a public health problem that’s triggered by painful events other than war-related experiences.

That wider perception of PTSD symptoms has evolved over the years to include a broader scope of direct traumas — like experiencing a serious car accident, life-threatening illness, violent physical assault or other traumatic events — as well as indirect ones (hearing about the death of a loved one).

By the numbers, 60 percent of all men and half of all women in America will experience at least one traumatic event and roughly 8 percent of all Americans will face PTSD during their lifetimes, according to the National Center for PTSD.

Now that modern science better understands the gut-brain axis (the connection that links your intestines, emotions and brain) more fully, it’s not at all surprising to learn the balance of bacteria in your gut may predict if you’ll experience PTSD or not, according to a study appearing in Psychosomatic Medicine.

The gut bacteria drop-off

Researchers at the University of Colorado and Stellenbosch University (South Africa) teamed up to compare the microbiomes of 18 patients with PTSD with a control group of 12 patients who experienced significant trauma but not PTSD to identify any abnormalities in the gut.

PTSD patients had dramatically lower levels of three bacterial species (Actinobacteria, Verrucomicrobia and Lentisphaerae) compared to the control group. Additionally, patients who experienced childhood trauma had lower levels of two species (Actinobacteria and Verrucomicrobia).

This second finding interests and worries researchers because people who experience childhood trauma are at a higher risk of facing PTSD later in their lives. In fact, these changes in gut health balance may have happened much earlier in response to childhood trauma, says lead researcher Dr. Stefanie Malan-Muller, according to a press release.

Another problem with this gut bacteria drop-off: All three are responsible for regulating the body’s immune system, and inflammatory markers soon after a traumatic event are an indicator that predicts the development of PTSD later on, says Dr. Malan-Muller.

Hopefully, more research will determine if this specific fall in gut bacteria makes patients more vulnerable to PTSD or if it occurs as a result of PTSD.

Could probiotics be used to treat PTSD? Researchers at the University of Colorado were impressed by the results of their 2016 study on preventing a PTSD-like syndrome in mice by adding beneficial bacteria to their tiny microbiomes.

Currently, this team of researchers is studying the key factors that lead to the development of PTSD in hopes their findings can lead to better treatments. A potential treatment the team is looking is one that alters microbiome with the use of probiotics containing a strain of Lactobacillus (one of the families of beneficial bacteria contained in EndoMune Advanced Probiotic and EndoMune Junior Probiotic for kids) and prebiotics.

Stay tuned to the EndoMune blog for more news about PTSD and other health information that affects your gut health.

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How Gut Health Affects Your Sleep, Your Brain

You’ve probably heard a lot in the news about sleep hygiene, the behaviors and practices that you can do to protect and enhance your slumber time, and why that’s so important for your health.

However, one of those benefits – a healthier brain – can be at risk if you aren’t sleeping well, and changes in your gut may be the tell-tale sign, according to a study appearing in Sleep Medicine.

Over the course of the study, researchers monitored the sleep habits and gut health of 37 healthy patients (ages 50-85) who provided fecal samples and completed assessments for sleep, mental acuity, diet and overall health.

The interesting findings here were positive connections with two specific phylum of bacteria in the gut: Verrucomicrobia and Lentisphaerae.

Higher amounts of both bacteria were associated to positive results – better sleep quality and good cognitive flexibility (your brain’s ability to switch between two different concepts or consider many concepts at the same time).

It certainly makes sense that sleep and our brains can be affected by these disruptions, given the growing amount of research that has shown how our gut bacteria follow a 24-hour circadian, wake/sleep schedule.

This inter-dependence between the gut and your circadian rhythms could also make your body more vulnerable to changes that promote obesity. Not to mention, we’ve also discussed how your circadian rhythms can get disrupted more easily due to jet lag, particularly when you travel long distances.

A growing number of experts believe gut health is linked to healthy sleep. “Scientists investigating the relationship between sleep and the microbiome are finding that the microbial ecosystem may affect sleep and sleep-related physiological functions in a number of different ways: shifting circadian rhythms, altering the body’s sleep-wake cycle, affecting hormones that regulate sleep and wakefulness,” says Dr. Michael Breus, a fellow at the American Academy of Sleep Medicine, according to The Guardian.

As research continues on the gut-sleep connection, Dr. Breus suggests taking a probiotic along with a prebiotic in the meantime to feed your gut.

Separate from ensuring you follow good sleep hygiene and eat the right foods, keeping your gut and brain in alignment is as simple as taking a high-quality probiotic, like EndoMune Advanced Probiotic, that contains 10 strains of beneficial bacteria and Fructooligosaccharides (FOS), a prebiotic that feeds the microbes in your gut and may help you sleep better too.

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More Food Additives May Harm Your Gut

We warned you recently about a gut bacteria connection to nitrites, a common food additive that may be a trigger for migraines. However, nitrites aren’t the only potential problem harming your gut health.

Your gut health may undergo changes or be compromised by chemical preservatives added to an array of foods, based on the results of two new studies.

Are antimicrobials benign?

As we’ve seen time and again, the use of antibacterial soaps and antibiotics has created unintended problems that have often made us too clean for our good.

Antimicrobial compounds work like antibacterials, with one key exception: Antibacterials prevent the spread of bacteria alone, while antimicrobials eliminate a wider range of critters, including viruses, yeasts, fungi and bacteria.

In a surprise to scientists at the University of Massachusetts, one specific antimicrobial compound – the food-grade polymer, polylysine — was responsible for the temporary disruption of gut bacteria in mice, according to a study appearing in Science of Food.

Polylysine is used as a food preservative in Korea and Japan as well as foods imported to America. (It’s commonly used in boiled rice, noodles, cooked rice and sushi.)

Over 15 weeks, researchers studied fecal samples taken from male and female mice that were fed polylysine at three different times (the beginning then at five and nine weeks).

“The concentrations of gut microbes changed in response to polylysine as we fed the mice throughout the study,” said Dr. David Sela, a nutritional biologist and lead study author, according to a press release.

“Surprisingly, the microbiome snapped back to the original concentrations despite continuous feeding of the polylysine, but we don’t understand how or the potential relevance to health.”

By week 5 of their study, the microbiomes of mice given polylysine had changed, but shifted back to normal at week 9.

It’s obvious that the microbiomes of mice adapted to this antimicrobial compound for reasons scientists can’t explain. Is that a good thing? And, how does this affect gut health over a longer time?

Is wine harming your gut?

Researchers at the University of Hawai’i Maui were far more definitive about the effect sulfites – a food preservative used in baked goods, beer and wine and canned vegetables just to name a few — have on the beneficial bacteria in your body, and it’s not good.

FDA regulations limit sulfites in processed foods to 5,000 parts per million, not a great amount. Nevertheless, some people are very sensitive to sulfites and must avoid them.

Researchers exposed four bacterial species in the human microbiome (from the Lactobacillus and Streptococcus families) to concentrations of two common kinds of sulfites (sodium bisulfite and sodium sulfite) in smaller concentrations (10-3,780 ppm) for up to six hours for a study appearing in PLOS One.

Unfortunately, these sulfites were responsible for killing or inhibiting the growth of beneficial bacteria, results that lead researcher Dr. Sally Irwin says could be a direct link between diseases and changes in the human microbiome.

Yes, food additives are a problem for people who are sensitive to them, but these results certainly shed a new light on what’s considered “safe” and “healthy.”All the more reason to protect and fortify your health with a multi-species probiotic like EndoMune Advanced Probiotic with 10 essential species of beneficial bacteria plus a prebiotic that feeds the good guys in your gut.

Can Yogurt Treat Depression?

Yogurt is a delicious and nutritional treat people often confuse as a remedy for all sorts of health conditions (often with the sneaky help of science).

But can yogurt treat depression, one of the most pervasive, frustrating and common health problems affecting more than 16 million adults in America annually?

A recent study appearing in Scientific Reports concluded feeding mice a proprietary strain of Lactobacillus reuteri in yogurt made from live cultures was enough on its own to reverse depressive symptoms in stressed out mice.

A team of scientists at the University of Virginia’s School of Medicine came to that finding after studying the gut health of tiny mice and discovering the depletion of Lactobacillus reuteri triggered the onset of depression.

To take it a step further, that loss of Lactobacillus reuteri was responsible for spiking levels of kynurenine (a metabolite in blood) that bring on depressive symptoms. Once mice were fed Lactobacillus reuteri with their food, however, their stress levels returned to nearly normal, scientists said.

This research does represent evidence that the gut-brain axis – the link between your brain, emotions and intestines – is very much a reality, and maintaining a healthy balance among all three is critical for good physical and mental health.

University of Virginia scientists were so pleased with these results on mice, they plan to turn their attention to human subjects, specifically with multiple sclerosis patients who struggle with depression too.

However, one probiotic strain may not be enough to do the trick. Other studies have found probiotics formulated with Bifidobacterium longum may have a similar beneficial effect on treating depression.

What’s more, there’s no guarantees the yogurt you’ll find in a grocery store will contain exactly the right amounts or combinations of beneficial bacteria that make much of a difference on balancing your emotions.

But, there is growing evidence that a probiotic containing multiple strains of beneficial bacteria – think EndoMune Advanced Probiotic — may be a more effective solution for treating depression and a safer one given all of the side effects associated with antidepressants.

Why Do I Need to Take a Probiotic?

For people who are reading our blog for the very first time or those needing a refresher course in good gut health habits, you may be wondering why we devote so much space to explaining why you need to take a probiotic.

There are A LOT of reasons for taking probiotics, in addition to promoting good gut health! Fortunately, you don’t have to do the research.

What follows are 10 important reasons why you should be taking probiotics for your good health, based on the latest research.

  1. Many cheap brands of probiotics contain a single strain of beneficial bacteria, which may be good for a specific problem. However, a multi-strain probiotic protects the diversity of your gut and treats common gut health problems like constipation too.
  1. Do you use an over-the-counter medication like loperamide (Imodium) to treat a case of diarrhea? Taking a probiotic is one of the most effective ways, not only to get rid of diarrhea, but to prevent it altogether.
  1. Irritable bowel syndrome (IBS) can do great harm to your gut and your emotions, disrupting your body’s gut-brain axis. Taking a probiotic and a prebiotic (EndoMune Advanced Probiotic and Endomune Jr. Probiotics for Kids contains both) may be a good way to treat IBS and depression without a drug.
  1. Are you taking antibiotics more than once a year to treat persistent infections? Antibiotics rapidly deplete the beneficial bacteria and make you more vulnerable to serious diseases such as colon cancer and more serious antibiotic-resistant infections. Taking a daily probiotic gives your body extra protection by replenishing the beneficial bacteria your body needs.

(You’ll also do your health a great deal of good by avoiding contact with antibacterial soaps that contain broad spectrum and synthetic antimicrobial compounds like triclosan too.)

  1. For patients who suffer from migraines, scientists have recently discovered a link between those painful headaches and nitrates, a common food additive. Some gut health experts believe taking a probiotic may become a safer, non-drug answer to treat migraines.
  1. Have problems with your teeth? Taking a probiotic is good treatment, as it may be a one more way to heal chronic periodontitis and reduce inflammation and levels of gingivitis and plaque, in addition to regular dental care.
  1. Hypertension can be a warning sign of serious health problems behind the scenes and even death. Taking a daily probiotic can improve your overall health, lower your blood pressure safely and lessen your dependence on prescription medications.
  1. Do you fly for your job or pleasure on a frequent basis or work a swing shift? The balance of bacteria in your gut is affected your body’s circadian rhythms as you cross time zones — often due to jet lag — but taking a probiotic prevents that yo-yo effect from harming your health.
  1. Protecting your sleep is an important part of restoring your body night after night. Be sure that any probiotic you consider taking also contains a prebiotic that can help you improve your sleep.
  1. Are you a new parent losing sleep over your baby’s prolonged crying due to colic? A number of studies point to probiotics as a safe, healthy way to lessen colic and prevent other common problems for babies like acid reflux and constipation.

Your Gut Bacteria Have a 24-Hour Routine

Messing up your body’s circadian rhythms — the behavioral, mental and physical changes that follow a 24-hour cycle — can have a huge effect on your health and gut.

Merely traveling on an airplane across multiple time zones can trigger jet lag, a temporary sleep problem when your body’s internal rhythms and biological clock are out of sync.

Apparently, your gut bacteria have a circadian schedule too, and a pair of studies shows how they affect your health for better and worse.

Following a schedule

Research by scientists at the Weizmann Institute of Science on mice in a study appearing in Cell demonstrated how gut bacteria follow a schedule, adapting to changes in light and dark, metabolic fluctuations and even the timing of our meals, says Dr. Eran Segel.

In fact, your microbiome moves around within the gut and are exposed to different species and varying numbers of species over the course of a 24-hour day.

Moreover, those changes brought on by circadian rhythms affect not only the physiology of the body but tissues and organs like the liver. Those rhythms can even govern how your body may metabolize and detoxify a drug as basic as acetaminophen.

Scientists also learned how the circadian rhythms of the bodies of little mice (and perhaps humans too) are very dependent on the workings of the microbiome. Surprisingly, genes that show no signs of circadian rhythms take over when these microbial rhythms are disrupted too.

These findings were observed when researchers gave mice antibiotics that removed much of their gut bacteria and even when their feeding times were changed.

Circadian rhythms and obesity

This inter-dependence between the gut and the body’s circadian rhythms could play a role behind the scenes in promoting the accumulation of body fat that leads to obesity, according to a recent study conducted at the University of Texas Southwestern and published in the journal, Science.

Based on tests that compared the health of germ-free, conventionally raised and genetically modified mice, scientists learned how the microbiome controls fat uptake and storage by “hacking into” and altering the functions of the circadian clocks within cells that line the gut.

They identified the mechanism by which gut bacteria regulate the composition of body fat and use a chemical (circadian transcription factor NFIL3) to establish a critical molecular link between the microbiota, circadian clock and metabolism, says Dr. Lora Hooper, lead author of the study, according to a press release.

So how does the microbiota hack into the lining of the gut?

A body’s circadian clock senses those day and night cycles, which are linked closely to feeding times, and transmits that information to the gut to turn on and off the metabolism (the uptake of lipids) when necessary.

More specifically, the circadian rhythms of the gut control the expression of NFIL3 and the production of lipids that are governed by this chemical in the intestinal lining.

“So what you have is a really fascinating system where two signals from the environment come in – the microbiome and the day-night changes in light – and converge on the gut lining to regulate how much lipid you take up from your diet and store as fat,” says Dr. Hooper.

How does this affect you?

Our go-go-GO! lifestyles create all sorts of havoc with our sleep schedules and often distract us from eating healthy meals on a timely basis, creating an environment for all sorts of health problems down the line.

Eating a balanced diet and getting the right amount of sleep your body needs every night really matters. And, we’ve learned in these studies, so does the health of the human gut, especially if you do a lot of traveling or work a crazy schedule that mixes daytime and nighttime hours.

That’s why it’s so important to give the health of your gut an added boost by taking a multi-species probiotic, like EndoMune Advanced Probiotic, that features 10 proven and protective strains of beneficial bacteria and a prebiotic that feeds the good bugs and may improve your sleep too!

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