Metabolic Inefficiency

Review of Clinical Trials of Probiotics and Prebiotics for Improving Metabolic Inneficiency

Dr. Lawrence Hoberman


Digestive health has a significant impact on overall health. We are all born with beneficial gut bacteria. Poor diet, stress, and taking antibiotics can disrupt this healthy balance, causing an overgrowth of harmful bacteria. When this happens, our immune systems react, triggering inflammation that leads to gastrointestinal maladies such as gas, bloating, diarrhea, constipation, and Irritable Bowel Disease (IBD).

Frustrated by the lack of options to treat his patients suffering from IBD, Dr. Lawrence Hoberman met with a PhD microbiologist to identify a combination of bacteria that might work to destroy the harmful bacteria living in the intestines, improving and maintaining the health of adults. The result of his efforts was a formula of 10 bacteria strains and 20 billion colony forming units (CFUs) for adults, and 4 bacteria strains of 20 billion CFUs for children.

Metabolic Syndrome

During his participation in a health and wellness program, Dr. Hoberman found, upon conducting comprehensive well exams, most patients who were overweight also exhibited symptoms of metabolic syndrome – elevated cholesterol, blood pressure, and diabetes – all major contributors to cardiovascular disease. A 2014 study revealed that gut bacteria present in obese individuals differs from that present in lean individuals. In obese individuals, bacteria harvest calories and direct them to be stored in the liver or as fat, while the bacteria in lean individuals harvest calories that are then burned.

This research motivated Dr. Hoberman to develop a unique formulation of the good bacteria present in lean people plus a prebiotic to nourish and support the beneficial bacteria. Prebiotics – starches that can’t be broken down by our intestinal tract – undergo fermentation that in turn produce beneficial chemicals that affect satiety, stomach motility, and insulin sensitivity.

Seventy percent of patients taking this formulation have experienced improvement in weight and insulin levels.

Board-certified gastroenterologist Lawrence Hoberman, MD, is the creator of EndoMune Metabolic Rescue, EndoMune Advanced Probiotic, and founder of Medical Care Innovations.