Constipation

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5 Reasons Why You Need to Take a Probiotic

If you’re seeing our blog for the first time — or the tenth time — you may be wondering why we share tips and news about the ever-changing, ever-shifting, ever-growing world of gut health many times each month in this space.

Our lives — full of work, life responsibilities and stress — leave us so little free time just to be…

Many of us fail to take even the very simple and necessary step of protecting our gut health by taking a probiotic every day.

Gut health affects so many parts of our own health and well-being, that a natural boost with a probiotic can make a world of difference to keep our bodies working just as they should.

Need some solid evidence that probiotics can make a world of difference to your health? Consider these five questions when you’re considering why you need to take a probiotic for your health, based on the latest research.

Have you taken a lot of antibiotics?

People rely so much and so often on antibiotics as a quick fix to solve all sorts of health problems — even minor ones like colds and sore throats — that doctors tend to over-prescribe them.

This excessive use has created an antibiotic-resistant world in which these drugs are quickly losing their ability to do the healing work they were meant to do.

The problems have become so acute that more people than ever are being sickened from exposure to superbug infections like Clostridium difficile (C. diff.) and some will die from them.

Antibiotics deplete the beneficial bacteria in your gut that keep your immune system strong. If you really need an antibiotic to solve a health problem, to take a probiotic two hours before taking an antibiotic to give those beneficial bacteria some extra time to reach and protect your gut.

Have you felt constipated lately?

Even a common gut-related health problem like constipation can be a sign of more serious health problems like irritable bowel syndrome (IBS) and kidney disease. Taking a probiotic restores the healthy balance of bacteria in your gut and lessens the need for harsher medications like mesalazine.

How are your emotions?

Disruptions in your gut-brain axis — the vital link that connects your gut, emotions and intestines — can add to challenges you may have with your sleep, mental health and mood. Taking a multi-species probiotic every day protects your gut’s ability to produce neurotransmitter chemicals like serotonin.

Could eating fermented foods help or hurt your gut?

Depending on how they’re prepared, fermented foods — such as pickles, yogurt, kombucha tea, pickles and miso — don’t provide the dependable gut health benefits that probiotics do and, in some cases, create more problems for your health than they’re worth.

Are you having trouble sleeping?

Shifts in your body’s circadian clock (the biological levers that control your wake-sleep schedule) due to work schedules or traveling long distances affect your gut health. Taking a quality probiotic that also contains a prebiotic (food for the good bugs in your gut) can help you get your sleep schedule back on track.

When evaluating a quality probiotic, you’ll want to consider a product that contains multiple strains of proven and beneficial bacteria and a prebiotic like EndoMune Advanced Probiotic and EndoMune Junior Advanced Probiotic.

BONUS QUESTION: How is your bone health?

If you’re having trouble maintaining your bone health, probiotics aid the production of butyrate (short-chain fatty acids created when your gut processes soluble fiber) that may increase bone mass.

European Journal of Public Health

Frontiers in Psychiatry

Journal of the American Society of Nephrology

BioMed Research International

Sleep Medicine

Microorganisms

Immunity

Mayo Clinic

Graphic with lists of good bacteria and bad bacteria in your gut.

The IBS/Traveler’s Diarrhea Connection

The holiday travel season may be long over, but the memories of that special trip, maybe to a warmer destination many time zones and thousands of miles away, still resonates.

Your only sour memory of that trip is a bad case of traveler’s diarrhea, the most common ailment vacationers face when they journey long distances, particularly to international destinations like South America, Africa, Mexico and Asia.

That run-in with traveler’s diarrhea could leave you vulnerable to irritable bowel syndrome (IBS), the most common gut health problem that affects up to 15 percent of all Americans, according to the American College of Gastroenterology.

A weakened immune system

Although researchers are still trying to figure out all of the answers, a recent study may have found an important connection between IBS and traveler’s diarrhea, according to a recent study appearing in the journal Cell.

To support a healthy gut, our body’s immune system must be equipped to maintain a balanced response to problems as they come without overdoing it.

For example, inflammation can help the gut fight an infection, but too much of a response “can cause lasting harm,” says Dr. Daniel Mucida, head of The Rockefeller University’s Laboratory of Mucosal Immunology.

After Dr. Mucida and his team treated mice with a weak form of Salmonella (a very common bacterium that causes food poisoning), they discovered a lingering drop of neurons in the gut that could create an inflammatory response.

Previous work by Dr. Mucida determined these neurons could also be triggering the death of a specialized set of gut immune cells that can lead to constipation, a key IBS symptom.

A gut bacteria imbalance

Not surprisingly, this research team also discovered treating mice with Salmonella tipped the balance of beneficial gut bacteria in their tiny bodies in a bad way.

However, those neurons recovered when scientists restored the healthy balance of bacteria in those very same mice.

Fortunately, one of critical steps you should take to prevent traveler’s diarrhea — taking a probiotic — works very well when treating IBS too.

That being said, not just any kind of probiotic will do the trick.

Many probiotics are formulated with a single strain of bacteria to treat a specific problem, but not the kinds that patients encounter with IBS.

Based on a very recent review in the journal Nutrients, patients experienced greater benefits when taking probiotics with multiple strains of beneficial bacteria for at least eight weeks.

The human gut is populated by more than 1,000 species of bacteria. A probiotic made with multiple strains of beneficial bacteria is formulated to boost your immune system and treat IBS more effectively.

Taking a product like EndoMune Advanced Probiotic made from 10 strains of beneficial bacteria from the Lactobacillus and Bifidobacterium families plus a prebiotic (FOS) that feeds the good bugs in your gut may be the safer and more effective choice for treating IBS and traveler’s diarrhea too.

References

CDC.gov

Cell, Vol. 180, Issue 1

The Rockefeller University

Nutrients, Volume 11, Issue 9

Gut Microbiota For Health

Picky Eater Child Refusing To Eat

Your Picky Eating Kid May Be Experiencing Constipation

Does your child experience constipation?

Like gas, constipation is a pretty common health issue, but another gut-related problem most people, especially kids, don’t like talking about.

More than 18 percent of toddlers and about 14 percent of kids ages 4-18 face problems with constipation, based on recent research.

Some signs your child has issues with chronic constipation — bowel movements occurring no more than twice a week or soiling (unintentional leakage of stool or liquid on the underwear) due to a buildup of stool — are pretty apparent.

Some less noticeable problems kids experience include:

  • Pain in their stomach or while having a bowel movement.
  • Hard-to-pass bowel movements.
  • Holding in stools that can cause complications.

You may be surprised to learn your child’s picky eating habits could explain his/her constipation problems too.

Sensory issues

Underlying sensory issues experienced by preschool-age kids who are developing normally may be playing a key role in chronic constipation, according to a recent study appearing in The Journal of Pediatrics.

“In many cases, chronic constipation might be the first hint that the child also has some sensory issues and could benefit from occupational therapy,” says senior author Dr. Mark Fishbein, a pediatric gastroenterologist and associate professor at the Northwestern University Feinberg School of Medicine.

Dr. Fishbein and his team of scientists in Chicago and Miami compared the health of 66 children (ages 3-5) dealing with chronic constipation with an equal number of control subjects with no health issues.

Part of their attention focused on how picky eating showed up in how kids responded to sensory stimuli.

Researchers soon learned that a heightened sensitivity to tastes, odors and textures in foods was the most important factor in predicting a child’s tendency to avoid the bathroom or becoming constipated.

The link between sensory sensitivity and constipation may not be apparent to the naked eye, says Dr. Fishbein. “However, increased sensory sensitivity can create discomfort and lead to avoidance, and we see that response in both food refusal and in the toileting behaviors of children with chronic constipation.”

Because these sensory problems are really common among children, Dr. Fishbein warns that it’s best to address this issue when kids are young, ideally before age 5, before these behaviors become harder to solve.

What parents can do

Treating your child’s constipation will take some time, persistence and patience on your part, but there’s light at the end of the tunnel — literally — if you follow these tips:

  1. Monitor your child’s daily intake of water (give them more) and milk (give them less).
  2. Work with your daughter or son to make regular visits to the toilet (make it fun).
  3. Feed your child foods containing dietary fiber, especially fruits and veggies (more is better).
  4. Don’t overdo the dosage of any laxative suggested by your child’s pediatrician (too much can be dangerous).

Have you considered giving your child a probiotic for constipation too? A recent report featured in Frontiers in Cellular and Infection Microbiology found probiotics increased the number of times kids pooped each day, which goes a long way toward solving the constipation problem.

EndoMune Jr. Advanced Probiotic Powder (for children up to age 3) and EndoMune Jr. Advanced Chewable Probiotic (for children from ages 3-8) are multi-strain probiotics that contain four key strains of beneficial bacteria and a prebiotic that can work wonders in treating constipation.

Could Constipation Shut Down Your Kidneys?

As our understanding of the human gut grows, modern medicine has come to realize that constipation is a much more prevalent and serious health problem and far less benign that we ever realized.

In fact, constipation may be a symptom of greater health problems, from hormonal issues to diabetes, colon cancer and multiple sclerosis.

Add chronic kidney disease to that list of serious diseases, based on a recent study appearing in the Journal of the American Society of Nephrology.

Researchers at the University of Tennessee’s Health Science Center and Memphis Veterans Affairs Medical Center discovered the link as they studied and monitored the health of some 3.5 million veterans for nearly a decade.

Compared to healthy patients, those suffering from constipation were 13 percent more susceptible to chronic kidney disease, and 9 percent were more likely to develop kidney failure, necessitating dialysis treatments or a kidney transplant.

The link between constipation and chronic kidney disease may be an uncomfortable blessing in disguise, because there are few signs or symptoms in the early stages.

What’s more, a cluster of health problems ranging from diabetes and high blood pressure to obesity and heart disease can increase your risks of chronic kidney disease too, blurring that simple connection to constipation.

“Our results suggest the need for careful observation of kidney function trajectory in patients with constipation, particularly among those with more severe constipation,” says Dr. Csaba Kovesdy, chief of nephrology at the Memphis Veterans Affairs Medical Center, according to a press release.

Right now, constipation is nothing more than a warning sign of chronic kidney disease. However, if constipation is found to play a more active role in this disease based on future research, Dr. Kovesky believes simple lifestyle adjustments and taking a probiotic may be enough to protect a patient’s kidney health.

Taking a probiotic with multiple species of beneficial bacteria like EndoMune Advanced Probiotic is a safe, proven way to boost the healthy diversity of your gut microbiome to treat constipation safely, effectively and without a drug.

Your Gut Health Connection to Parkinson’s

Now that modern science has finally embraced the gut-brain axis, it was only a matter of time before researchers began to find other pathways that connect the two.

Recent studies have linked both to Parkinson’s disease, one of the most common neurological brain disorders Americans face. Parkinson’s is a neurodegenerative disorder related to the brain’s shrinking production of dopamine, which leads to problems with tremors, stiffness and balance.

Interestingly, your gut health connection to Parkinson’s disease may be tied to some common problems, like constipation and imbalances in gut bacteria.

Does Parkinson’s start in the gut?

One study, appearing in Neurology, examined the health of patients receiving resection surgery or a vagotomy, a procedure that removes the main portion or branches of the vagus nerve, the longest cranial nerve in the human body extending from the neck to the abdomen, to treat ulcers.

Researchers discovered the gut health connection to Parkinson’s when comparing two types of vagotomy surgeries that fully or selectively (partially) resected the vagus nerve.

Over the scope of the 40-year study, three times as many patients who had a selective vagotomy eventually developed Parkinson’s versus a full resection. Plus, patients who had a full resection were 40 percent less likely to experience Parkinson’s.

The “bread crumbs” left behind by a partial resection led researchers to conclude that Parkinson’s origins may start in the gut, says study author Dr. Bojing Liu, MSc, of the Karolinska Instituet in Stockholm, Sweden, according to a press release.

In fact, gut health problems like constipation that manifest decades sooner may be a sign that Parkinson’s could emerge later on in a patient’s life, says Dr. Liu.

Can a gut bacteria imbalance lead to Parkinson’s?

A lot closer to home, researchers at the University of Alabama at Birmingham (UAB) may have found another telltale sign of Parkinson’s disease via the composition of bacteria that inhabit the human gut.

Scientists discovered the connection while comparing the health of some 200 patients from three distinct regions of America (Northwest, Northeast and Southeast) with Parkinson’s to 130 healthy controls, according to the study appearing in Movement Disorders.

Unfortunately, health experts couldn’t figure out what came first:

  • Are changes in a patient’s gut bacteria balance a red flag that Parkinson’s is a possibility?
  • Does this disease play an active part in the disruption of gut health?
  • Could a Parkinson’s drug be causing problems?

One clue that may determine which way this gut bacteria imbalance goes is the method in which the microbiome helps the body get rid of environmental pollutants not typically found in the human body.

The balance of bacteria tasked with eliminating these chemicals was different in Parkinson’s patients, a critical finding since exposure to herbicides and pesticides in farm settings increases one’s risk of this debilitating disease.

These discoveries may lead to new treatments for Parkinson’s disease, says Dr. Haydeh Payami, a professor in the Department of Neurology at the UAB School of Medicine, according to UAB News.

Therapies that regulate the imbalance in the microbiome may prove to be helpful in treating or preventing the disease before it affects neurologic function.”

Could taking a multi-species probiotic like EndoMune Advanced Probiotic be a possible solution?

While scientists were quick to discourage any quick fixes, taking a probiotic does boost the body’s natural immunities and is a healthy and effective way to treat constipation without a drug.

Multi-species probiotics conquer constipation

All by itself, constipation is a serious health problem accounting for some 2.5 million visits to American doctors, not to mention a growing number of trips to the ER. Constipation is also one of the telltale symptoms of irritable bowel syndrome (IBS), a chronic condition that affects the colon.

In the past, people have attempted to treat their IBS symptoms with drugs like mesalazine and mexiletine with only mixed results and a lot of unwanted side effects.

The real problem with taking these kinds of drugs is that they don’t get to the root cause of the problem: Rebuilding the healthy balance of beneficial bacteria in the gut.

Taking a multi-species probiotic can do a great deal of good, not only in restoring that gut healthy balance, but treating IBS symptoms associated with constipation too, according to a recent Italian study appearing in BioMed Research International.

For their randomized, double-blind study, scientists divided 150 IBS patients (all adults between age 18-65) with constipation issues into three groups, including one who received a placebo, for 60 days.

Interestingly, three of the five strains of beneficial bacteria in the multi-species probiotic given to patients — blends of Lactobacillus rhamnosus, Lactobacillus plantarum and Lactobacillus acidophilus — are contained in EndoMune Advanced Probiotic.

Compared to the placebo group, the major symptoms of IBS patients taking a multi-species probiotic improved from 74-82 percent compared to just 40 percent for the placebo group.

Even better, patients in both probiotic groups enjoyed relief from symptoms 30 days after the end of supplementation. In fact, signs of some beneficial bacteria were present in stool samples taken from patients too.

This study provides more evidence that taking a probiotic can be a much safer, healthier solution for treating constipation, especially the variety connected with IBS and a lot of other gut-related problems.

Again, the real trick is taking a probiotic made with multiple strains of bacteria from three key “families” (plus a prebiotic) like EndoMune Advanced Probiotic that supports the diversity of bacteria that inhabit your gut.

How to get rid of constipation

How to get rid of constipation?

Have you ever experienced such a bad case of constipation that you considered going to the ER? Don’t be embarrassed. A growing number of Americans have made that trip, according to a recent report in The American Journal of Gastroenterology.

After collecting data from more than 950 U.S. hospitals, researchers found the number of emergency room visits related to constipation rose from nearly 500,000 in 2006 to more than 700,000 in 2011, an increase of 41 percent.

In addition to the growing number of constipation-related ER visits, patient costs rose by more than 50 percent.

Of all age groups, younger and senior patients suffered the most. A 2006 study shows that infants under age 1 visited the ER most frequently, followed by geriatric patients above age 84.

Alarmingly, the number of children ages 1-17 in need of ER treatment increased over 50 percent from 2006-11. This group also represented the second largest age group making ER-related visits due to constipation.

These recent numbers certainly add to the 2.5 million visits patients making visits to their doctors or gastroenterologists for constipation, as cited by the American College of Gastroenterology.

What You Can Do About It

As mentioned before in this space, the lack of a hard-and-fast definition for constipation can be a problem. Although it’s often described as the inability to have regular bowel movements, your regularity may vary depending on your diet, exercise levels and age.

According to the Mayo Clinic, other signs that you or a loved one may be suffering from constipation could be:

  • Straining to complete a bowel movement.
  • Feeling a blockage that prevents a bowel movement.
  • Producing lumpy or hard stools.
  • Needing help (pressing on your abdomen) to finish a bowel movement.

Medical experts say the underlying causes of constipation could range from medication side effects to hormonal issues and serious diseases such as multiple sclerosis, colon cancer and diabetes.

Fortunately, many cases of constipation are easily treatable by following these common steps:

  • Keep your body hydrated by drinking plenty of water.
  • Be sure to incorporate more fiber-rich foods into your daily diet.
  • Stop sedentary living and get moving with a little exercise every day.
  • Schedule plenty of time in the bathroom to complete a bowel movement.
  • Take a probiotic with multiple strains of beneficial bacteria, like EndoMune Advanced Probiotic or EndoMune Junior (for kids).

If these simple steps do not relieve your constipation problems, please make an appointment with your primary care physician. Doing so could prevent a painful trip to the ER.

Going or Not Going: Relieve Constipation Safely

Constipation is an uncomfortable health problem that can make for painfully awkward conversations. This is why Americans often turn to family physicians or gastroenterologists when constipation becomes a concern.

Constipation is responsible for some 2.5 million visits to a doctor or specialist annually in America, according to the American College of Gastroenterology.

There is no hard-and-fast definition for constipation, but it’s often described as the inability to have more than three bowel movements per week. However, some people who experience only three bowel movements weekly are still healthy, depending on their age, diet and daily physical activity.

Telltale signals you may want to see your doctor about a constipation problem include straining, hard stools and incomplete evacuation occurring in more than 25 percent of bowel movements, according to WebMD.

Common, less serious causes of constipation:

  • Living a sedentary lifestyle.
  • Forgetting to drink enough water.
  • Not eating enough fiber-rich foods.
  • Postponing a necessary trip to the bathroom.
  • Failing to deal with life’s stressors.

A more serious problem

Constipation can be a more costly and serious health problem than you assume, according to a 2009 report published in Clinical Gastroenterology and Hepatology.

Some 63 million people living in America suffer from constipation every year, according to the National Digestive Diseases Information Clearinghouse, and spend $235 million annually to treat it. Researchers also found links between constipation and a number of painful health problems:

Hemorrhoids: Straining during a bowel movement may cause veins in lower rectum to swell or become inflamed.

Anal fissure: These small tears in thin, moist tissue may happen when you pass large or hard stools during a bowel movement.

Fecal incontinence: Constipation, along with diarrhea and muscle or nerve damage, may cause an inability to control bowel movements.

Colon cancer risks increase with chronic constipation

The health outcomes become even more serious if you experience chronic constipation, according to a 2012 study that compared the health of nearly 29,000 patients suffering from persistent constipation to some 87,000 healthy patients. The risk of colon cancer nearly doubled among patients with chronic constipation while the incidence of benign tumors (neoplasms) increased nearly threefold.

Colon cancer is nothing to ignore, as it’s the third most common cancer and the second leading cause of death among all cancer types in the U.S.

“Although chronic constipation is considered a relatively benign disease, practitioners should be aware of this potential association to monitor and treat accordingly,” said Dr. Nicholas Talley of the University of Newcastle and co-investigator of this study. “We encourage anyone with questions related to their condition to talk to their health care professional so that the specific health needs of each patient can be balanced with the risks and benefits of medications.”

Relieve constipation

One of the popular medications people use to treat constipation — sodium phosphate laxatives — was the subject of a recent FDA warning, based on patients exceeding the recommended daily dosage of this over-the-counter remedy.

The FDA’s Adverse Event Reporting System showed a single dose of sodium phosphate per day was associated with rare, but serious damage to a person’s lungs and heart.

Children under age 5, baby boomers over age 55 and people diagnosed with or taking medications for kidney disease are among the patient groups who are at the greatest risk of serious complications when laxative dosage is exceeded. (Children under age 2 should not be given the rectal form of sodium phosphate.)

Taking a probiotic with multiple strains of beneficial bacteria, like EndoMune, is a safer treatment for constipation that has the added advantage of boosting your immune system, reducing your risks of colon cancer and maintaining normal intestinal motility.

10 Reasons Everyone Should Take a Probiotic

With 100 trillion bacteria and many different species of microflora floating around in our intestinal tract, a balance of good and bad bacteria is necessary to maintain the normal functioning of our immune system and intestines, as well as to promote optimal health.

Considering the recent attention being paid to probiotics—many positive medical studies have been reported in the mainstream media—more people are asking why they need to take a probiotic to protect and improve their overall health.

Here are 10 reasons to take a probiotic for your good health:

1. Your body is under constant attack externally (from exposure to bad bacteria) and internally (our go-go lifestyles hinder our eating habits). Taking a good probiotic, ideally with multiple strains of good bacteria, is the safest, easiest and most effective way to maintain a healthy balance of good bacteria in your body.

2. The human body cannot replenish the various strains of live and beneficial bacteria your body needs every day to stay healthy just by eating foods like yogurt, miso soup, pickles and sauerkraut that usually contain limited amounts of a single strain of bacteria. This is especially true if you’re using probiotics to treat a specific health problem.

3. Probiotics containing multiple strains of beneficial bacteria are more effective in treating a range of health-based problems, including irritable bowel syndrome (IBS), diarrhea, immune function and respiratory tract infections, according to a 2011 analysis of studies.

4. A growing number of studies are showing how taking a probiotic can be beneficial for patients when they are prescribed a broad spectrum antibiotic. Antibiotics can often disrupt the balance of good and bad bacteria in patients’ bodies, causing unwelcome side effects like diarrhea.

5. Taking a good probiotic boosts patients’ natural defenses, protecting them from traveler’s diarrhea, too.

6. New moms can sidestep the prolonged crying and discomfort from their babies suffering infantile colic by giving them a high-quality probiotic.

7. Recent studies have been linked with taking a high-quality probiotic to beneficial effects on the gut-brain axis that may positively affect your emotions and help you beat depression.

8. The healthy bacteria contained in a good probiotic help maintain normal intestinal motility and lessen the problems of constipation.

9. Reducing your risks of colon cancer is as simple as taking a good probiotic.

10. Probiotics are a newfound weapon that may assist in lowering elevated blood pressure and cholesterol levels that contribute to cardiovascular disease.

To Go or Not To Go… that is the problem

Dear EndoMune subscribers,

Now that we are enjoying the beauty of the spring days, we really don’t want to be slowed down by any GI issues. The following real case report describes how EndoMune can make a positive difference in your health this season:

Case Study: Constrained By Constipation

Karen, a 34-year old corporate executive, saw her primary care physician due to a problem of constipation. Karen had a longstanding history of difficulty with normal stool habits. She had tried a variety of diets and laxatives with no real improvement.

A comprehensive gastroenterological evaluation did not reveal any abnormality. She was told that her problem was due to “irritable bowel syndrome.”

The physician recommended a high fiber diet, stool softeners and exercise.

Karen continued to have problems with bloating, distention and constipation. Her GI issues made it hard for her to function at work. Enjoying outdoor activities like hiking and biking with her family were difficult.

Karen read about probiotics and decided to try EndoMune.

After one week of therapy, Karen’s constipation markedly improved. She was so delighted with the results that she emailed to let me know how EndoMune had made such a difference in her life.

The Discomfort of Constipation

After reading the case report, it is apparent that this month’s newsletter is about how probiotics can ease the problem of constipation.

Constipation is a common condition affecting children and adults. In the vast majority of cases, no underlying natural cause is found and functional constipation or “irritable bowel syndrome” is diagnosed.

Did you know that:

Constipation is medically defined as less than 3 stools per week and associated with straining1

Constipation is one of the most common GI disorders in clinical practice

Approximately 20% of the general population suffers from chronic constipation during their lifetime

Childhood constipation accounts for 3-5% of all visits to pediatricians2

Approximately 70-80% of nursing home residents have constipation3

Finding Relief

In the last 5-6 years, there have been a number of medical studies evaluating whether probiotics can improve constipation and associated symptoms. Not all of them have shown benefit.

I have listed the results of some of the most well done studies:

In 2011, Guerra et al4 reported the results of a study involving 59 children suffering with constipation. Over a 10-week period, the group receiving probiotics had significant improvement in stool frequency, consistency and less abdominal pain.

In 2011, Waller et al5 published a study done on 100 adults with chronic constipation. The group receiving probiotics for 14 days had significantly improved stool frequency and decreased abdominal symptoms compared to the control group.

In 2010, Hyang et al6 reported the results of a clinical study using probiotics in a group of nursing home patients. After 2 weeks of therapy, there was a significant improvement in frequency and consistency of the stools.

In addition to improving GI function, there were no adverse side effects associated with the use of probiotics in these medical studies. This is a very important and unique benefit of probiotic use when compared to other constipation therapies.

How probiotics improve intestinal function is being actively researched by medical experts. Studies7 have found that the bacterial flora in constipated individuals is different than in individuals with regular bowel movements in that they lack the ability to produce beneficial fermented products that enhance intestinal function. Adding probiotics reestablishes a healthy intestinal flora resulting in improved intestinal activity.

Take Home Message

If you struggle with GI issues, consider adding EndoMune to your daily regimen and enjoy these beautiful spring days comfortably!

Eat healthy, exercise and take EndoMune!

Best Wishes,

Lawrence Hoberman MD

1) Epidemiology of constipation in North America: a systematic review.Higgins PD, Johanson JF.Am J Gastroenterol. 2004 Apr;99(4):750-9. Review

2) Epidemiology of childhood constipation: a systematic review.van den Berg MM, Benninga MA, Di Lorenzo C.Am J Gastroenterol. 2006 Oct;101(10):2401-9. Review.

3) Chronic Constipation in the Elderly free Juan F Gallegos-Orozco, Amy E Foxx-Orenstein, Susan M Sterler & Jean M StoaThe American Journal of Gastroenterology 107, 18-25
doi:10.1038/ajg.2011.349

4) Pediatric functional constipation treatment with Bifidobacterium-containing yogurt: a crossover, double-blind,controlled trial.Guerra PV, Lima LN, Souza TC, Mazochi V, Penna FJ, Silva AM, Nicoli JR, Guimarães EV.World J Gastroenterol. 2011 Sep 14;17(34):3916-21.

5) Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults.Waller PA, Gopal PK, Leyer GJ, Ouwehand AC, Reifer C, Stewart ME, Miller LE.Scand J Gastroenterol. 2011 Sep;46(9):1057-64. Epub 2011 Jun 13.

6) Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents.An HM, Baek EH, Jang S, Lee do K, Kim MJ, Kim JR, Lee KO, Park JG, Ha NJ.Nutr J. 2010 Feb 5;9:5.

7) Functional dysbiosis within the gut microbiota of patients with constipated-irritable bowel syndrome (pages 828–838) C. Chassard, M. Dapoigny, K. P. Scott, L. Crouzet, C. Del’homme, P. Marquet, J. C. Martin, G. Pickering, D. Ardid, A. Eschalier, C. Dubray, H. J. Flint and A. Bernalier-DonadilleAlimentary Pharmacology and Therapeutics, 03/19/2012

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