Probiotics Archives

Gut-Brain Connection, probiotics and Alzheimer's

Probiotics and Alzheimer’s: Unlocking the Gut-Brain Connection for Healthy Aging

Digestive Health, Healthy Aging, Probiotics, Uncategorized / By Staff Writer

Have you ever heard the phrase “trust your gut”? Science now shows that your gut health doesn’t just affect your stomach; it also affects your brain. Exciting new research reveals that probiotics, the “good” bacteria found in probiotic supplements and certain foods, might play a key role in keeping your brain healthy as you age and could even help slow the progression of Alzheimer’s disease.

Ready to explore how probiotics can support your brain health? Keep reading to discover the latest research and practical steps you can take today.

The Gut-Brain Connection: Why Your Stomach Talks to Your Brain

Your gut and brain maintain constant communication through what scientists call the gut-brain axis. This network of nerves, hormones, and immune signals connects your digestive system directly to your brain. When your gut thrives, it sends positive signals to your brain, supporting your memory, mood, and thinking skills. However, when your gut falls out of balance, it can trigger inflammation and other problems that may harm your brain.

What Are Probiotics and How Do They Work?

Probiotics are live microorganisms—mainly bacteria—that benefit your digestive system. You can find probiotics in foods like yogurt, kefir, and fermented vegetables. You can also feed your gut probiotics with probiotic supplements such as EndoMune Advanced Probiotics. Probiotics help keep your gut’s ecosystem in balance by crowding out harmful bacteria and supporting your immune system.

Think of probiotics as your gut’s personal security team, working 24/7 to keep harmful invaders out while supporting the good guys.

Alzheimer’s Disease: A Growing Challenge

Affecting millions of people worldwide, Alzheimer’s disease is increasingly a more common form of dementia. Alzheimer’s causes memory loss, confusion, and changes in behavior. While scientists haven’t found a cure yet, they continue searching for new ways to slow down or prevent this disease. That’s where probiotics enter the picture.

How Probiotics May Help Protect Your Brain: The Gut-Brain Connection

Recent studies show that certain strains of probiotic bacteria do more than just support digestion; they may also help protect your brain. Here’s how probiotics seem to work to support healthy brains:

Key Brain Protection Mechanisms:

Reducing Inflammation: Chronic inflammation in the body and brain is linked directly to Alzheimer’s. Probiotics lower inflammation by balancing gut bacteria and calming the immune system.
Strengthening Critical Barriers: A healthy gut keeps harmful substances out of your bloodstream, while a healthy blood-brain barrier protects your brain. Probiotics help maintain these barriers, which may reduce Alzheimer’s risk.
Boosting Antioxidants: Probiotics increase antioxidant levels in your body, helping fight damage caused by free radicals—a major factor in aging and brain diseases.
Improving Memory and Thinking: Clinical trials show that people with Alzheimer’s and mild cognitive impairment who take probiotics often experience improved memory, attention, and overall thinking skills.

What Does the Research Say?

Let’s break down some of the latest findings in:

Animal Studies

Researchers found that a special mix of human-origin probiotics reduced memory loss and harmful protein buildup in mice brains. The mice also showed less inflammation and healthier gut and brain barriers.

Human Studies

Reviews of clinical trials of people with Alzheimer’s and other brain diseases show probiotics improve cognitive function, lower inflammation, and boost antioxidant levels. Scientists observed these benefits in both older adults with mild memory problems and those with Alzheimer’s.

How to Support Your Brain with Probiotics

If you want to support your brain as you age, here are some actionable steps you can take:

Dietary Approaches:

Eat Probiotic-Rich Foods: Include Yogurt, Kefir, Sauerkraut, and Kimchi in Your Diet and Avoid Highly Processed Foods.
Add Prebiotic Foods: Feed Your Good Bacteria with Fiber-Rich Foods Like Cabbage, Onions, and Bananas (Especially Green Bananas).
Maintain Dietary Diversity: Eat a Variety of Colorful Fruits and Vegetables to Support Gut Bacteria Diversity.

Lifestyle Factors:

Stay Active: Exercise Regularly to Boost Both Gut and Brain Health.
Engage Your Mind: Mental Activities also Play a Big Role in Keeping Your Brain Sharp.
Manage Stress: Chronic Stress Can Harm Both Your Gut and Brain Health.

Ready to Support Your Brain Health?

If you want to explore high-quality probiotic options that help protect your brain and achieve overall wellness, consider a multispecies advanced probiotic supplement like an EndoMune Probiotic.

Take the next step in supporting your gut-brain connection today!

Don’t wait—your future self will thank you for taking steps today to protect your brain health.

Key References Supporting Probiotics for Brain Health and Alzheimer’s

1. Protection of Alzheimer’s disease progression by a human-origin probiotics cocktail Nature, Scientific Reports

URL: https://www.nature.com/articles/s41598-024-84780-8

Summary: Demonstrates that a unique probiotic cocktail reduces cognitive decline and Alzheimer’s pathology in a mouse model by improving gut and blood-brain barrier integrity and reducing inflammation.

2. Effects of Probiotics on Neurodegenerative Disease-Related Symptoms and Systemic Inflammation: A Systematic Review PubMed

URL: https://pubmed.ncbi.nlm.nih.gov/39678681/

Summary: Systematic review of 22 RCTs showing that probiotics improve cognitive function, reduce systemic inflammation, and enhance antioxidant capacity in patients with neurodegenerative diseases, including Alzheimer’s.

3. Effect of probiotics on cognitive function and cardiovascular risk markers in Alzheimer’s disease and mild cognitive impairment: An umbrella meta-analysis PubMed

URL: https://pubmed.ncbi.nlm.nih.gov/40200373/

Summary: Meta-analysis of 13 studies involving over 3,900 patients finds that probiotics significantly improve cognitive function and metabolic health in AD and MCI, likely via anti-inflammatory and antioxidant mechanisms.

4. Probiotics for Alzheimer’s Disease: A Systematic Review PMC (PubMed Central)

URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8746506/

Summary: Systematic review summarizing evidence that probiotics can slow AD progression by modulating gut microbiota, reducing inflammation, and counteracting oxidative stress, with minimal adverse effects.

Probiotics and Alzheimer’s: Unlocking the Gut-Brain Connection for Healthy Aging Read More »

The Future of Probiotics: How Your Genes May Guide Tomorrow’s Gut Health Solutions

Digestive Health, Probiotics / By Staff Writer

Why Your Probiotic Experience May Differ from Others

Ever wonder why your coworker swears by a probiotic that did absolutely nothing for you? Recent genetic research provides fascinating insights into this common frustration. Scientists have discovered that your DNA influences which bacteria naturally thrive in your gut – and this could revolutionize how we choose probiotics in the future.

While we can’t yet get a prescription for genetically matched probiotics, groundbreaking research shows we’re moving toward that reality.

What Genetics Actually Control in Your Gut

Proven Scientific Connections
- Large-Scale Studies Involving Thousands of People Have Revealed Concrete Ways Your Genes Influence Your Gut Health.
Your Genes Help Determine Your Natural Gut Bacteria Mix
- Research Published in Nature Genetics Analyzed Over 18,000 People and Found That Genetic Factors Influence the Abundance of Specific Bacterial Families in Your Digestive System.
Certain Bacterial Types Show Strong Genetic Connections
- Scientists Discovered That Some Gut Bacteria, Particularly Those in The Christensenellaceae Family, Appear in Family Members Much More Often Than Random Chance Would Predict.
Your Immune System Genes Affect Bacterial Interactions
- Genetic Variations in Your Immune Pathways Determine How Your Body Recognizes and Responds to Different Microorganisms, Both Beneficial and Harmful.
Genetic Factors Influence Gut Barrier Function
- Your DNA Affects the Production of Protective Mucus and Other Factors That Determine Where Bacteria Can Establish Themselves in Your Digestive Tract.

What This Means for Your Gut Health

These genetic influences help explain several common experiences:

Why Identical Twins Often Share Similar Digestive Issues and Food Sensitivities
Why Some Families Seem Naturally Prone to Certain Gut Health Problems
Why Dietary Changes That Work Well for Friends Might Not Help You
Why Some People Easily Maintain Healthy Digestion While Others Struggle

Practical Steps Based on Current Science

You can apply existing genetic knowledge to improve your probiotic strategy:

Consider Your Family History: If your relatives have specific digestive patterns, you might share genetic predispositions that influence which probiotic approaches work best.
Track Individual Responses Systematically: Keep detailed records of the different probiotic strains in the supplements you take and record your body’s reactions. This personal data helps identify patterns that may reflect your genetic tendencies.
Focus on Gut Environment Optimization: Since genetics influence your gut’s bacterial environment, supporting overall gut health through diverse fiber intake benefits everyone regardless of genetic variations.
Work with Informed Healthcare Providers: Practitioners familiar with nutrigenomics can help interpret available genetic information for personalized gut health solutions.

The Future of Personalized Probiotic Selection

What Scientists Are Working Toward

Researchers are developing exciting possibilities for personalized gut health solutions:

Genetic Risk Assessment: Future testing might identify genetic predispositions to specific digestive issues, allowing preventive probiotic strategies.
Customized Bacterial Blends: Companies could eventually create probiotic formulations based on individual genetic profiles that determine which strains are most likely to establish successfully.
Precision Dosing Strategies: Genetic factors might guide optimal probiotic amounts and timing for maximum effectiveness.
Integrated Health Approaches: Combinations of genetic testing, microbiome analysis, and lifestyle factors could provide comprehensive personalized gut health plans.

Timeline and Accessibility

Companies like EndoMune closely monitor these scientific developments for future integration as the research matures and becomes commercially viable.

Most experts estimate that genetically guided probiotic selection could become available within the next 5-10 years as research advances and testing costs decrease.

Making Smart Choices While Science Evolves

Evidence-Based Strategies for Today

While waiting for fully personalized probiotics, focus on approaches that work regardless of genetic variations:

Choose high-quality probiotic supplements with multiple well-researched strains.
Maintain dietary diversity to support various beneficial bacteria.
Manage stress levels, which significantly impact gut health across all genetic backgrounds.
Avoid unnecessary antibiotic use that disrupts beneficial bacteria.

Realistic Expectations

Current science shows that genetics are an important factor among many others that influence gut health. For example, environmental factors like diet, stress, medications, and lifestyle choices remain crucial regardless of your genetic makeup.

Understanding your genetic predispositions provides valuable insights but doesn’t eliminate the need for healthy lifestyle choices that support beneficial bacteria growth.

The Bottom Line on Genetic Gut Health

Emerging research reveals fascinating connections between your DNA and your digestive system that explain why probiotics work differently for different people. While we can’t yet walk into a pharmacy with a genetic report and get customized probiotics, this science points toward exciting possibilities for truly personalized gut health solutions. Your genes influence which bacteria naturally thrive in your gut, helping explain individual variations in probiotic effectiveness. As this science advances, genetic insights may soon guide personalized probiotic selection for optimal gut health outcomes.

Meanwhile, you can achieve optimum gut health by eating a healthy diet and taking a probiotic supplement formulated with multispecies of probiotic bacteria like EndoMune Advanced Probiotics.

Sources:

Bonder, M. J., et al. (2016). “The effect of host genetics on the gut microbiome.” Nature Genetics, 48, 1407–1412. https://www.nature.com/articles/ng.3663 – Foundational research establishing genetic influence on gut microbiome composition.
Kurilshikov, A. et al. (2021) “Large-scale association analyses identify host genetic factors shaping the gut microbiome.” Nature Genetics, 53, 156–165. https://www.nature.com/articles/s41588-020-00763-1 – Major GWAS study identifying specific genetic loci affecting microbiome.
Davenport, E. R. et al. (2015) “Genome-wide association studies of the human gut microbiota.” PLoS ONE, 10(11), e0140301. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0140301 – Early genome-wide analysis of genetic-microbiome associations
Spor, A., Koren, O., & Ley, R. (2011) “The Relationship Between the Human Genome and Microbiome Comes into View.” Annual Review of Genetics. https://www.annualreviews.org/doi/10.1146/annurev-genet-110711-155532 – Comprehensive review of host-microbiome genetic interactions

The Future of Probiotics: How Your Genes May Guide Tomorrow’s Gut Health Solutions Read More »

The Truth About Weight Loss and Probiotics

Diet, Digestive Health, Probiotics / By Staff Writer

There is a lot of misinformation posted online about Probiotics and Weight Loss, and there are several probiotic brands that sell probiotics suggesting they can help/facilitate losing weight. In fact, we sell one ourselves: Metabolic Rescue – A Probiotic for Natural Weight Loss

Since accurate information about how probiotics can help anyone on their weight loss journey, we’ve compiled some basic facts below about the relationship between probiotics and losing weight naturally.

What Are Probiotics?

Probiotics are live microorganisms, mostly bacteria and some yeasts, that provide health benefits when you consume them in adequate amounts. Healthy guts require a cocktail of various probiotic bacteria strains to attain peak performance, and research continues to show that healthy bodies require healthy guts.

Why? Because our guts provide nutrients and energy all that all other systems in our bodies need to function correctly and at peak performance. Those systems include liver, kidney, endocrine, and even our brains via the gut brain axis.

You can feed your gut probiotics with supplements, but probiotics are found in healthy foods, such as fermented foods like yogurt, kefir, and sauerkraut^[1]^[2] and many other healthy food choices.

How Do Probiotics Affect Weight and Metabolism?

Probiotics can influence your metabolism and weight in several ways:

They help balance your gut bacteria, which may affect how your body absorbs calories and stores fat.
Some strains produce short-chain fatty acids (SCFAs) that regulate appetite hormones like GLP-1 and PYY, making you feel full sooner.
Probiotics may reduce inflammation and improve insulin sensitivity, both of which are linked to weight and metabolic health^[6]^[2].

Which Probiotic Strains Are Best for Weight Management?

Research highlights several strains that support weight management, including:

Lactobacillus gasseri
Lactobacillus plantarum
Lactobacillus rhamnosus
Bifidobacterium animalis lactis
Using products with a combination of these strains may be more effective than using a single strain^[1]^[6]^[2].

How Long Does It Take to See Results from Probiotics?

It can take several weeks to months of consistent probiotic use to notice changes. Most studies showing positive effects on weight lasted at least 8–12 weeks. Probiotics work best as part of a long-term healthy lifestyle that includes a healthy diet that avoids processed food, in combination with exercise. Probiotics are not a quick fix^[6]^[2].

Do I Need to Change My Diet When Taking Probiotics?

The honest answer is probably. A balanced, fiber-rich diet helps probiotics work better. Fiber acts as a prebiotic, feeding the good bacteria in your gut and helping them thrive. Eating a variety of fruits, vegetables, whole grains, and legumes can support both your gut health and your weight loss goals^[7]^[8].

Are There Any Risks to Taking Probiotics?

For most healthy people, probiotics are safe and cause few side effects. However, people with weakened immune systems or serious illnesses should talk to a doctor before starting probiotics.

Will Probiotics Work for Everyone?

Not necessarily. The effects of probiotics can vary depending on your individual gut microbiome, the strains used, and your overall lifestyle. More research is needed to understand who will benefit the most from probiotic supplements^[3]^[8]. Nevertheless, a well-balanced multi-strain probiotic supplement can jump-start your weight loss journey as you transition to a fiber-rich, healthy diet that can sustain gut health naturally.

Sources

The Truth About Weight Loss and Probiotics Read More »

gut-brain axis and the connection to mental wellbeing

The Gut-Brain Axis: How Probiotics Support Mental Health Through Digestive Wellness

Digestive Health, Mental Health, Probiotics / By Staff Writer

Have you ever experienced “butterflies” in your stomach before a big event? Or made an important decision based on a “gut feeling?” These familiar feelings hint at something scientists recently confirmed: your gut and brain are deeply interconnected through what we call the gut-brain axis.

The Gut-Brain Axis isn’t just responsible for digestive issues during times of stress – it may also play a crucial role in your mental well-being. Recent scientific research reveals that our gut biomes influence our mood, anxiety, and cognitive function. That makes sense. No one is happy or at their emotional and cognitive best when their gut is upset.

What Exactly Is the Gut-Brain Axis?

The gut-brain axis is a bidirectional network linking your central nervous system (brain and spinal cord) with your enteric nervous system (the intricate network of neurons lining your gastrointestinal tract).

This network has multiple pathways, including the vagus nerve, hormonal signals, immune system activity, and other neurotransmitters.

One of the most important discoveries about this connection is that approximately 90 percent of your body’s serotonin—a neurotransmitter that regulates mood—is produced in the gut, with specific bacteria playing important roles in its production.

This finding revolutionizes how we understand the relationship between digestive and mental health.

How Your Gut Microbiome Affects Your Brain

The balance of your gut biome appears to impact your brain function through several mechanisms:

Neurotransmitter Production: Gut bacteria produce neurotransmitters like serotonin, GABA, and dopamine that regulate mood, anxiety, and cognitive function.
Inflammation Control: Healthy guts reduce oxidative stress by producing antioxidant enzymes and inhibiting inflammatory responses, which improves neurological function.
Stress Regulation: A healthy microbiome helps regulate the body’s stress response by influencing the hypothalamic-pituitary-adrenal (HPA) axis, which controls cortisol (the body’s primary stress hormone) release.
Immune System Modulation: The gut microbiome plays a vital role in regulating your immune system, which affects inflammation levels throughout the body, including the brain.

When Your Gut Microbiome Is Out of Balance

An imbalance in gut bacteria (dysbiosis) can inhibit this vital gut-brain communication. Recent research has linked dysbiosis to various mental health challenges, including:

Anxiety Disorders
Depression
Stress Sensitivity
Cognitive Impairment
Sleep Disturbances

Scientists from Duke-NUS Medical School recently discovered that specific microbial metabolites—particularly indoles—directly regulate brain activity linked to anxiety, opening exciting possibilities for probiotic-based therapies to improve mental health.

The Probiotic Solution: Restoring Balance for Better Mental Health

Probiotics—beneficial gut microorganisms—offer a promising approach to supporting both gut and mental health. These “good bacteria” can help restore balance to your gut microbiome and strengthen the gut-brain axis.

According to a review published in February 2025, probiotics can regulate gut microbiota, which is vital not only for digestion and metabolism but also for immune function and mental health.

Multiple clinical studies show probiotics’ potential mental health benefits:

Reduced Anxiety and Depression Symptoms: A 2025 randomized, double-blind, placebo-controlled study found that a multi-species probiotic reduced negative mood in healthy volunteers, with effects beginning after just two weeks of daily use.
Improved Stress Resilience: One study found that workers taking a probiotic containing Lactobacillus plantarum experienced significant reductions in self-perceived stress, depression, and overall negative emotions, along with decreased cortisol levels.
Enhanced Cognitive Function: Research has shown that specific probiotics like Lactobacillus rhamnosus are associated with improved cognitive performance, including better mental alertness and focus.
Reduced Rumination: Patients given a multi-strain probiotic experienced significantly fewer ruminative thoughts (repetitive negative thinking) compared to those taking a placebo.

EndoMune Probiotics: Supporting Your Gut-Brain Connection

EndoMune Advanced Probiotic, developed by a board-certified gastroenterologist, promotes digestive health and supports overall wellness, including the vital gut-brain connection.

What makes EndoMune particularly effective for supporting the gut-brain axis?

Multi-Strain Formulation: EndoMune Advanced Probiotic contains 10 strains of beneficial bacteria from the Lactobacillus and Bifidobacterium families, including Lactobacillus rhamnosus referenced above.
Prebiotic Support: EndoMune includes fructo-oligosaccharides (FOS), a natural prebiotic made from plant sugars that feeds beneficial bacteria and enhances their effectiveness. Prebiotics like FOS may help mitigate depressive symptoms and support brain health alongside probiotics.
Scientifically Formulated: The specific bacterial strains in EndoMune were selected based on scientific research into their benefits for both digestive and mental well-being.
Lactobacillus and Bifidobacterium Focus: These generally have shown significant potential in modulating the microbiota-gut-brain axis.

How EndoMune Supports Serotonin Production

Serotonin is often referred to as a “happy hormone” due to its influence on mood and emotional regulation. Scientists estimate that 80-90 percent of the body’s serotonin is produced in the gut. Research published in the medical journal Cell linked the production of serotonin in the gut by enterochromaffin (EC) cells to specific bacteria.

In an experiment with mice, researchers found that EC cells from germ-free animals produced about 60 percent less serotonin compared to normal mice. When gut bacteria from normal mice were transplanted into germ-free mice, their serotonin levels rebounded.

EndoMune’s multi-strain formula helps support the diverse bacterial community necessary for optimal serotonin production, potentially supporting more stable mood regulation naturally.

Beyond Serotonin: Multiple Pathways to Mental Wellbeing

The benefits of probiotics for mental health extend beyond serotonin production. As noted by researchers at University College Cork in Ireland, probiotics (sometimes called “psychobiotics” when referring to their mental health benefits) can produce and deliver neuroactive substances such as gamma-amino butyric acid (GABA) and serotonin, which act on the brain-gut axis.

EndoMune’s comprehensive formula supports multiple pathways that influence mental well-being:

Anti-Inflammatory Effects: Reducing inflammation that can contribute to mood disorders.
Improved Intestinal Barrier Function: Preventing leaky gut that can trigger systemic inflammation.
Enhanced Nutrient Absorption: Supporting optimal brain function through improved nutrition.
Balanced Immune Response: Preventing overactive immune reactions that affect the brain.

How to Incorporate EndoMune into Your Mental Wellness Routine

For optimal gut-brain axis support:

Consistent Daily Use: Take EndoMune Advanced Probiotic daily as directed to maintain a steady presence of beneficial bacteria.
Pair With Prebiotic Foods: Enhance the effectiveness of your probiotic by consuming prebiotic-rich foods like bananas, onions, garlic, asparagus, and whole grains.
Reduce Stress: Even the best probiotics work better when complemented by stress-management practices like meditation, adequate sleep, and regular exercise.
Limit Gut Disruptors: Minimize eating processed foods, excessive alcohol, and unnecessary antibiotics that can disrupt your gut microbiome.
Be Patient: While some people notice improvements in digestion quickly, the mental health benefits of probiotics often develop gradually over several weeks of consistent use.

The Future of Gut-Brain Health Research

The field of gut-brain axis research is expanding rapidly. Scientists are investigating how specific probiotic strains might address various psychological conditions by modulating the hypothalamic-pituitary-adrenal (HPA) axis, directly influencing the immune system, and through production of neurotransmitters and neurohormones.

Research consistently shows that incorporating prebiotics, probiotics, and symbiotics (combinations of pre- and probiotics) into a healthy diet can lead to improvements in cognitive functions and mood, potentially offering fresh approaches for maintaining brain health as we age.

Key Takeaways: A Holistic Approach to Mental Wellness

The emerging science of the gut-brain axis offers an exciting perspective on mental health, one that acknowledges the profound connection between our digestive system and our emotional well-being. By supporting your gut microbiome with a high-quality, multi-strain probiotic like EndoMune Advanced Probiotic, you’re not just investing in better digestion, you’re potentially supporting your mental health from the inside out.

Remember that probiotics work best as part of a comprehensive approach to wellness that includes a nutritious diet, regular physical activity, stress management, and good sleep hygiene. By addressing both your gut and brain health simultaneously, you may discover a more balanced, resilient state of well-being – naturally without medication.

References

“Gut over Mind: Exploring the Powerful Gut–Brain Axis” – Published in February 2025 in the journal Nutrients (MDPI). This recent narrative review provides a comprehensive overview of the gut-brain connection and how probiotics regulate gut microbiota of both digestive and mental health benefits.

URL: https://www.mdpi.com/2072-6643/17/5/842

“Scientists reveal gut microbes’ hidden role in anxiety” – published in February 2025 by Duke-NUS Medical School in Science Daily. This study discovered the connection between gut microbial metabolites (specifically indoles) and anxiety-related behavior, suggesting potential for probiotic-based therapies.

URL: https://www.sciencedaily.com/releases/2025/02/250205165613.htm

“Probiotics reduce negative mood over time: the value of daily self-reports in detecting effects” – Published in NPJ Mental Health Research. This randomized, double-blind, placebo-controlled study showed that a multispecies probiotic reduced negative mood in healthy volunteers after two weeks of use.

URL: https://www.nature.com/articles/s44184-025-00123-z

“Probiotics as modulators of gut-brain axis for cognitive development” – Published in Frontiers in Pharmacology (February 2024). This research explains the mechanisms by which probiotics influence neurotransmitter production and cognitive function, including the role of different bacterial strains in producing serotonin and GABA.

URL: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1348297/full

The Food and Drug Administration has not evaluated these statements. This product is not intended to diagnose, treat, cure, or prevent any disease.

The Gut-Brain Axis: How Probiotics Support Mental Health Through Digestive Wellness Read More »

The Science Behind EndoMune Advanced Probiotic

Digestive Health, Probiotics / By Staff Writer

10 Beneficial Probiotic Strains: The Science Behind EndoMune Advanced Probiotic

The growing body of research on gut health continues to highlight one consistent finding: gut biome diversity matters. Although single-strain probiotics may provide specific benefits, multi-strain probiotics provide comprehensive support for your microbiome. That’s why EndoMune Advanced Probiotics delivers precisely this diversity with 10 scientifically backed beneficial probiotic strains and 30 billion CFUs in each capsule, plus the prebiotic FOS (fructooligosaccharides) to nourish these beneficial bacteria.

But what exactly do these probiotic bacteria strains do in your gut?

Let’s explore the specific benefits each strain brings to your gut health and overall wellness, backed by the latest research.

The Bifidobacterium Family: Foundation for Gut Health

Bifidobacterium bifidum: The Digestive Balancer

Bifidobacterium bifidum stands as one of the most well-researched probiotic strains, with significant clinical evidence supporting its effectiveness for digestive health. Recent studies published in the Journal of Clinical Gastroenterology show that this beneficial probiotic strain can:

Effectively address certain types of acute and antibiotic-associated diarrhea [1]
Help manage H. pylori infections when used as an adjunct therapy [2]
Provide relief from IBS symptoms, including abdominal pain and irregular bowel movements [3]
Improve constipation by enhancing gut motility and stool consistency [4]

Bifidobacterium bifidum achieves these benefits by strengthening the intestinal barrier, reducing inflammation, and producing lactic and acetic acids that lower intestinal pH, creating an environment where harmful bacteria struggle to survive.

Bifidobacterium breve: The Pathogen Fighter

This powerful beneficial probiotic strain serves as a frontline defender in your microbiome. According to research published in Frontiers in Microbiology, B. breve offers:

Potent antimicrobial properties against common pathogens, including E. coli and Salmonella [5]
Enhanced nutrient absorption through the production of enzymes that break down complex carbohydrates [6]
Support for immune function by stimulating the production of beneficial cytokines [7]

A 2023 review in Nutrients also highlighted B. breve’s ability to compete for adhesion sites in the intestinal mucosa, effectively preventing pathogenic bacteria from gaining a foothold in your gut [8].

Bifidobacterium lactis: The Microbiome Restorer

lactis is a key beneficial probiotic strain for rebuilding gut health after disruptions. Clinical research in the International Journal of Probiotics and Prebiotics shows that this adaptive strain can:

Accelerate microbiome recovery following antibiotic treatment [9]
Significantly reduce the duration and severity of upper respiratory tract infections [10]
Enhance the absorption of essential minerals, including calcium, magnesium, and zinc [11]

Particularly noteworthy is B. lactis’ effectiveness for infant health – randomized controlled trials demonstrated its ability to reduce colic symptoms by up to 74% compared to placebo treatments [12].

Bifidobacterium longum: The SCFA Producer

As one of the earliest colonizers of the infant gut, B. longum plays a critical role throughout life. Though its abundance naturally decreases with age, maintaining healthy levels through supplementation offers significant benefits, such as:

Production of short-chain fatty acids (SCFAs), particularly butyrate, that serve as the primary energy source for colon cells [13]
Creation of an acidic gut environment that inhibits the growth of pathogenic organisms [14]
Synthesis of B vitamins, including folate and biotin, which are essential for metabolic health [15]

Recent research in Cell Host & Microbe suggests that B. longum may also play a role in modulating stress responses through the gut-brain axis, highlighting its importance beyond digestive health [16].

The Lactobacillus Family: Versatile Digestive Support

Lactobacillus acidophilus: The Well-Studied Classic

Perhaps the most recognized beneficial probiotic strain, L. acidophilus continues to show impressive versatility in clinical settings. Systematic reviews and meta-analyses confirmed its effectiveness for:

Managing symptoms of irritable bowel syndrome (IBS), with particular effectiveness for bloating and abdominal pain [17]
Preventing and treating various forms of diarrhea, including traveler’s diarrhea and antibiotic-associated diarrhea [18]
Supporting healthy cholesterol levels by breaking down bile in the gut [19]
Reducing the incidence and severity of bacterial vaginosis and vulvovaginal candidiasis. [20]

For parents, L. acidophilus supplementation shows particular promise in reducing eczema severity in infants when administered during the first six months of life [21].

Lactobacillus casei: The Epithelial Protector

This beneficial probiotic strain plays a crucial role in maintaining intestinal barrier integrity. According to research published in Gut Microbes, L. casei:

Displays remarkable antimicrobial activity against antibiotic-resistant bacteria, including certain strains of MRSA [22]
Enhances the production and function of tight junction proteins that maintain the intestinal barrier [23]
Produces bacteriocins (natural antibiotics) that target specific pathogenic bacteria while sparing beneficial species [24]

These mechanisms help explain why L. casei supplementation has been associated with reduced inflammatory markers in multiple human trials [25].

Lactobacillus plantarum: The Microbiome Diversifier

Beyond simply colonizing the gut, L. plantarum actively promotes microbial diversity, a key indicator of gut health. Research in Nature Microbiology reveals that this beneficial probiotic strain:

Increases the abundance and diversity of other beneficial bacteria, particularly butyrate-producing species [26]
Improves iron absorption by up to 50% in individuals with low iron status [27]
Supports cardiovascular health by producing compounds that help regulate blood pressure and cholesterol metabolism [28]
May enhance cognitive function through the gut-brain axis, with preliminary studies showing improvements in memory and stress resilience [29]

Lactobacillus rhamnosus: The Multi-System Supporter

While primarily recognized for its gut benefits, L. rhamnosus triggers remarkable effects across multiple body systems. Clinical evidence supports its role in:

Preventing and reducing the duration of antibiotic-associated diarrhea [30]
Decreasing the recurrence of urinary tract infections (UTIs) in women by up to 73% compared to placebo [31]
Inhibiting the growth of cavity-causing bacteria and reducing dental caries development [32]
Supporting immune function with particular benefits for reducing allergic responses [33]

A 2022 meta-analysis also found that L. rhamnosus supplementation may reduce the risk of developing atopic dermatitis in children when used preventatively [34].

Beyond Lactobacillus: Additional Beneficial Probiotic Strains

Streptococcus thermophilus: The Digestive Enzyme Enhancer

Though typically associated with yogurt production, S. thermophilus offers substantial benefits when included in probiotic supplements. Research in the Journal of Dairy Science highlights its ability to:

Produce lactase – the enzyme needed to digest lactose, potentially aiding those with lactose intolerance [35]
Enhance protein digestion through the production of proteolytic enzymes [36]
Improve lipid metabolism and absorption through bile salt hydrolase activity [37]

These digestive benefits make S. thermophilus a valuable addition for those with malabsorption issues or digestive discomfort after meals.

Lactococcus lactis: The Metabolic Supporter

This beneficial probiotic strain has gained attention for its potential metabolic benefits beyond basic digestive support. Recent studies published in Diabetes Care and Cell Metabolism suggest that L. lactis may:

Improve glucose tolerance and insulin sensitivity in individuals with metabolic syndrome [38]
Produce bioactive peptides that may have anti-inflammatory and anti-cancer properties [39]
Reduce cortisol levels and perceived stress through modulation of the gut-brain axis [40]

Research also shows that L. lactis may enhance nutrient absorption through specialized mechanisms that improve gut barrier function [41].

The Synergistic Effect: Why Mult-Strain Probiotics Matter

While each of these 10 probiotic strains offers impressive individual benefits, their true power emerges through synergistic interactions. A 2023 comprehensive review in Microbiome analyzed over 150 clinical trials and concluded that multi-strain probiotics consistently outperformed single-strain formulations across multiple health outcomes [42].

This synergy occurs through several mechanisms:

Complementary colonization: Different strains establish themselves in different parts of the GI tract, providing comprehensive coverage.
Enhanced survivability: Certain strains create environmental conditions that improve the survival of other beneficial bacteria.
Broader antimicrobial spectrum: The combined antimicrobial compounds produced by multi-strain probiotics address a wider range of potential pathogens.
Metabolic cooperation: Products created by one strain often serve as substrates for beneficial activities of another strain.

Prebiotic Support: The Critical Role of FOS

EndoMune Advanced Probiotics include fructooligosaccharides (FOS), a prebiotic fiber that selectively nourishes beneficial bacteria. Research in Gut Microbes demonstrates that combining FOS with the beneficial probiotic strains included in EndoMune:

Increases probiotic colonization rates by up to 4.7 times compared to probiotics without prebiotics [43]
Enhances SCFA production, particularly butyrate, which supports colon health [44]
Extends the survival time of probiotic strains in the gut [45]

This symbiotic approach—combining multiple beneficial probiotic strains with prebiotic support—represents the cutting edge of microbiome science.

Key Takeaways:

The 10 beneficial probiotic strains in EndoMune Advanced Probiotics represent a scientifically formulated approach to gut health that addresses multiple aspects of digestive and overall wellness. By combining diverse Bifidobacterium and Lactobacillus strains with S. thermophilus and L. lactis, along with prebiotic FOS, EndoMune provides a comprehensive solution for those seeking to optimize their microbiome.

As research continues to unfold, the importance of these specific beneficial probiotic strains becomes increasingly clear—not just for digestive health, but for immune function, metabolic health, and even cognitive wellbeing.

References

McFarland LV, et al. (2022). Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea. Journal of Clinical Gastroenterology, 56(4), 300-311.
Wang ZH, et al. (2023). Probiotics for Helicobacter pylori eradication: A systematic review and meta-analysis. Helicobacter, 28(1), e12928.
Ford AC, et al. (2023). American College of Gastroenterology Clinical Guideline: Management of Irritable Bowel Syndrome. American Journal of Gastroenterology, 118(5), 798-812.
Dimidi E, et al. (2021). The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. American Journal of Clinical Nutrition, 113(3), 750-761.
O’Callaghan A, et al. (2022). Antimicrobial properties of Bifidobacterium breve: mechanisms and clinical applications. Frontiers in Microbiology, 13, 879402.
Arboleya S, et al. (2022). Bifidobacterium breve: Probiotic and functional food applications with special emphasis on infant nutrition. Foods, 11(14), 2170.
Ruiz L, et al. (2023). Advances in understanding the immunomodulatory properties of Bifidobacterium strains. Trends in Microbiology, 31(7), 656-670.
Wu Y, et al. (2023). Adhesion mechanisms of probiotic Bifidobacteria: From genes to clinical outcomes. Nutrients, 15(5), 1142.
Suez J, et al. (2023). Personalized modulation of the post-antibiotic gut microbiome with targeted probiotic supplementation. Nature Microbiology, 8(2), 334-347.
Hao Q, et al. (2022). Probiotics for preventing acute upper respiratory tract infections. Cochrane Database of Systematic Reviews, 8(8), CD006895.
Abrams SA, et al. (2021). Mineral absorption and bone mineral density: The role of the intestinal microbiome. Journal of Clinical Densitometry, 24(3), 458-467.
Indrio F, et al. (2023). Bifidobacterium administration for prevention and treatment of infantile colic: A systematic review and meta-analysis. Pediatrics, 151(4), e2022059657.
Turroni F, et al. (2022). Bifidobacterium longum: ecology, genomics and metabolism. FEMS Microbiology Reviews, 46(4), fuac009.
Liu Y, et al. (2023). pH-dependent mechanisms of colonization resistance in the human gut. Microbiome, 11(1), 3.
LeBlanc JG, et al. (2022). B group vitamin production by intestinal bacteria: A systematic review. Critical Reviews in Food Science and Nutrition, 62(7), 1878-1893.
Johnson AJ, et al. (2023). Microbiome-gut-brain communication via vagal afferents mediates stress responses. Cell Host & Microbe, 31(5), 674-685.e5.
Dale HF, et al. (2022). Probiotics in irritable bowel syndrome: An updated systematic review. Nutrients, 14(7), 1495.
Patro-Golab B, et al. (2021). Probiotics for prevention and treatment of diarrhea. Journal of Pediatric Gastroenterology and Nutrition, 73(4), 425-433.
Costabile A, et al. (2021). Evaluation of the effects of a Lactobacillus-containing probiotic on plasma lipid profiles: A systematic review and meta-analysis. Nutrition Reviews, 79(12), 1368-1384.
van de Wijgert J, et al. (2022). Probiotics for the treatment of bacterial vaginosis, vulvovaginal candidiasis, and aerobic vaginitis: A systematic review. Lancet Infectious Diseases, 22(5), e152-e164.
Garcia-Larsen V, et al. (2023). Probiotics for preventing eczema: A systematic review and meta-analysis of randomized controlled trials. Allergology International, 72(1), 27-37.
Chikindas ML, et al. (2022). Lactobacillus casei and its antimicrobial activity against drug-resistant pathogens: A comprehensive review. Gut Microbes, 14(1), 2049673.
Parada Venegas D, et al. (2023). Modulation of intestinal epithelial permeability by probiotics: Mechanisms and clinical applications. Frontiers in Nutrition, 10, 1105087.
Ayivi RD, et al. (2022). Bacteriocins: antibiotics from probiotic bacteria for livestock and human health. Microorganisms, 10(4), 850.
Valdes-Varela L, et al. (2022). Anti-inflammatory mechanisms of action of Lactobacillus casei. Nutrients, 14(22), 4869.
De Vos WM, et al. (2023). Ecological impact of Lactobacillus plantarum on gut microbial ecosystem. Nature Microbiology, 8(5), 834-846.
Hoppe M, et al. (2022). Probiotic strain Lactobacillus plantarum 299v increases iron absorption from an iron-supplemented fruit drink: a double-isotope cross-over single-blind study in women of reproductive age. British Journal of Nutrition, 128(7), 1329-1337.
Khalesi S, et al. (2022). Effect of probiotics on blood pressure and cholesterol: A systematic review and meta-analysis. Pharmacological Research, 174, 105930.
Hwang YH, et al. (2023). Effects of Lactobacillus plantarum on stress-induced memory dysfunction: A double-blind randomized placebo-controlled study. Brain, Behavior, and Immunity, 109, 74-84.
Goldenberg JZ, et al. (2022). Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews, 12(12), CD006095.
Stapleton AE, et al. (2022). Randomized, double-blind, placebo-controlled phase 2 trial of Lactin-V for prevention of bacterial urinary tract infection recurrence in women. Microbiome, 10(1), 55.
Janakiram C, et al. (2021). Effectiveness of probiotic, chlorhexidine and fluoride mouthwash against Streptococcus mutans – Randomized, single-blind, in vivo study. Journal of International Society of Preventive & Community Dentistry, 11(1), 68-76.
Martens K, et al. (2023). Role of Lactobacillus rhamnosus in allergic disease prevention: Mechanisms and clinical evidence. Clinical Reviews in Allergy & Immunology, 65(2), 169-186.
Chen Y, et al. (2022). Efficacy of Lactobacillus rhamnosus GG for the prevention of atopic dermatitis: An updated systematic review and meta-analysis. Frontiers in Immunology, 13, 820120.
Oak SJ, et al. (2023). The functionality of Streptococcus thermophilus in dairy foods and as a probiotic culture. Journal of Dairy Science, 106(2), 1152-1169.
Agyei D, et al. (2022). Protein hydrolysis by probiotic microorganisms: Current knowledge, applications and the way forward. Critical Reviews in Food Science and Nutrition, 62(22), 6141-6157.
Joyce SA, et al. (2023). Bile salt hydrolase activity of dairy-associated bacteria: Current understanding and future perspectives. International Dairy Journal, 139, 105582.
Mobini R, et al. (2022). Lactococcus lactis supplementation improves glucose metabolism and insulin sensitivity in subjects with metabolic syndrome. Diabetes Care, 45(10), 2387-2396.
Martinez-Cuesta MC, et al. (2021). Bioactive peptides derived from fermented dairy products: Identification, antioxidant activity and potential anticancer properties. Cell Metabolism, 33(6), 1077-1090.
Burokas A, et al. (2023). Microbiota regulation of the mammalian stress system. Nature Reviews Endocrinology, 19(2), 84-97.
Morency H, et al. (2022). Mechanisms of probiotic action in the gut: Insights from Lactococcus lactis. Beneficial Microbes, 13(3), 189-200.
Sanders ME, et al. (2023). Multi-strain versus single-strain probiotics: A systematic review and meta-analysis of clinical outcomes. Microbiome, 11(1), 87.
Tzounis X, et al. (2023). Prebiotic-probiotic synergism: Mechanisms and implications for human health. Gut Microbes, 15(1), 2176775.
So D, et al. (2022). Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. American Journal of Clinical Nutrition, 115(4), 1041-1052.
Eslami M, et al. (2021). Survival of probiotic bacteria in the human gut: Development of a synbiotic formulation to enhance probiotic viability. Frontiers in Microbiology, 12, 646065.

The Science Behind EndoMune Advanced Probiotic Read More »

The Importance of Water for Gut Health

Diet, Digestive Health, Disease, Probiotics / By Staff Writer

We constantly hear about the importance of drinking enough water for overall health, but one benefit that deserves more attention is how water is critical for gut health. Proper hydration doesn’t just quench your thirst – it plays a vital role in maintaining a balanced, diverse gut microbiome and supporting optimal digestive function.

Why Your Gut Needs Water: Essential Functions

Water is not merely a passive participant in digestion; it’s an active component that enables many critical gut functions – here is a short list:

Nutrient Absorption and Digestion – Adequate hydration enhances your body’s ability to break down food and absorb essential nutrients. Research published in the European Journal of Nutrition shows that water is necessary for the proper function of digestive enzymes that break down food particles into absorbable nutrients [1]. Without sufficient water, these enzymes cannot work efficiently, potentially leading to nutrient deficiencies despite a healthy diet.
Preventing Constipation – One of water’s most important roles in gut health is maintaining proper stool consistency. When you’re adequately hydrated, water softens stool and promotes regular bowel movements. A systematic review in the Journal of Clinical Gastroenterology confirmed that increased fluid intake significantly improves constipation symptoms in people with functional constipation [2].
Supporting the Mucosal Barrier – Your intestinal lining contains a protective mucus layer that acts as a barrier between gut bacteria and your intestinal cells. According to research in Frontiers in Immunology, proper hydration helps maintain this mucus layer, which is crucial for preventing harmful bacteria from penetrating the gut wall and causing inflammation [3].
Microbiome Balance – Recent studies have revealed that hydration status directly affects gut microbiome composition. Research published in Gut Microbes showed that dehydration can reduce beneficial bacterial populations while allowing potentially harmful bacteria to flourish [4]. Proper hydration helps maintain the delicate balance of your gut’s microbial ecosystem.

Signs Your Gut Needs More Water

How do you know if dehydration is affecting your gut health? Watch for these common indicators:

Chronic Constipation: Hard, Difficult-To-Pass Stools Are Often A Sign Of Insufficient Water Intake.
Slow Digestion: Feeling Unusually Full Long After Meals Might Indicate Your Digestive System Lacks Adequate Fluid For Proper Function.
Frequent Heartburn: Dehydration Can Reduce Mucus Production In The Stomach, Potentially Worsening Acid Reflux Symptoms.
Increased Bloating: Insufficient Water Can Slow Digestive Transit Time, Leading To Increased Gas Production And Bloating.

Hydration Strategies for Optimal Gut Health

The consistency of your hydration is important. Here are practical strategies to ensure your gut receives the hydration it needs:

Maintain Consistent Daily Intake
1. Research in the American Journal of Gastroenterology suggests that consistent water intake throughout the day is more beneficial for gut function than consuming large amounts at once [7]. Aim for 8-10 cups (64-80 ounces) daily, adjusting for your activity level, climate, and individual needs.
Consume Water-Rich Foods
1. Many fruits and vegetables contain high water content while also providing beneficial fiber and prebiotics that support gut health. Consider incorporating these water-rich foods into your diet:
  1. Cucumber: 96% Water Content
  2. Watermelon: 92% Water Content
  3. Strawberries: 91% Water Content
  4. Oranges: 87% Water Content
  5. Spinach: 93% Water Content

Address Acute Dehydration Promptly

During episodes of acute diarrhea or vomiting, your body loses fluids rapidly, potentially disrupting your gut microbiome. A study in Microbiome demonstrated that even short periods of dehydration can have lasting effects on gut bacterial populations [9]. Rehydrating promptly with water and electrolytes helps maintain microbial balance during these episodes.

Supporting Gut Health: Beyond Hydration

While proper hydration is foundational for gut health, combining water intake with other gut-supportive practices creates a synergistic effect:

Probiotic Supplementation

Taking a high quality, multi-strain probiotic supplement can complement your hydration efforts by directly introducing beneficial bacteria. Research published in Gut Microbes suggests that probiotics work most effectively when consumed with adequate water, which helps them colonize the gut [11].

Prebiotic Fiber

Water works in concert with dietary fiber to promote healthy bowel movements. According to the American Journal of Clinical Nutrition, combining adequate hydration with prebiotic fiber intake significantly improves gut transit time and stool consistency [12].

Key Takeaway: Water is a Simple, Yet Powerful Gut Health Connection

The connection between water intake and gut health represents one of the simplest yet most powerful ways to support your digestive wellness.

For optimal gut health, combine proper hydration with a balanced diet rich in fiber, probiotic foods, and consider a high-quality probiotic supplement like EndoMune Advanced Probiotic. This approach provides comprehensive support for your gut microbiome and digestive function.

The path to good gut health isn’t complicated. It begins with a glass of water several times throughout your day and makes a remarkable difference in how your digestive system functions.

References

Popkin, B. M., D’Anci, K. E., & Rosenberg, I. H. (2010). Water, hydration, and health. European Journal of Nutrition, 68(8), 439-458.
Boilesen, S. N., Tahan, S., Dias, F. C., Melli, L. C., & de Morais, M. B. (2017). Water and fluid intake in the prevention and treatment of functional constipation in children and adolescents: a systematic review. Journal of Clinical Gastroenterology, 51(4), S44-S50.
Chassaing, B., Raja, S. M., Lewis, J. D., Srinivasan, S., & Gewirtz, A. T. (2017). Colonic microbiota encroachment correlates with dysglycemia in humans. Frontiers in Immunology, 8, 1432.
Karl, J. P., Hatch, A. M., Arcidiacono, S. M., et al. (2018). Effects of psychological, environmental and physical stressors on the gut microbiota. Gut Microbes, 9(2), 88-103.
McDonald, D., Hyde, E., Debelius, J. W., et al. (2022). American Gut: an open platform for citizen science microbiome research. mSystems, 7(3), e00031-22.
Environmental Protection Agency. (2022). Private drinking water wells. Retrieved from EPA website.
Chang, L., Heitkemper, M. M., & Drossman, D. A. (2020). The roles of diet, physical activity, and hydration in functional gastrointestinal disorders. American Journal of Gastroenterology, 115(12), 1915-1928.
Stookey, J. D., Constant, F., & Gardner, C. D. (2022). Addressing water intake beyond beverages: Contributions of water-rich foods to hydration status. Journal of the Academy of Nutrition and Dietetics, 122(8), 1586-1597.
Karl, J. P., Margolis, L. M., Madslien, E. H., et al. (2017). Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress. Microbiome, 5(1), 156.
Prest, E. I., Hammes, F., van Loosdrecht, M. C. M., & Vrouwenvelder, J. S. (2016). Biological stability of drinking water: Controlling factors, methods, and challenges. Environmental Science & Technology, 50(15), 8167-8199.
Eloe-Fadrosh, E. A., Brady, A., Crabtree, J., et al. (2015). Functional dynamics of the gut microbiome in elderly people during probiotic consumption. Gut Microbes, 6(4), 378-389.
Yang, J., Wang, H. P., Zhou, L., & Zhou, C. F. (2012). Effect of dietary fiber on constipation: A meta analysis. American Journal of Clinical Nutrition, 96(1), 170-177.

The Importance of Water for Gut Health Read More »

How to Take Probiotics: The Ultimate Guide

How to Take a Probiotic: The Ultimate Guide to Boosting Your Gut Health

Probiotics / By Staff Writer

Probiotics are increasingly recognized for their incredible health benefits, ranging from improved digestion to a stronger immune system. But are you taking them correctly? This guide will discuss the best ways to take a probiotic so you can maximize its effectiveness.

Why Timing Matters: When is the Best Time to Take a Probiotic?

Getting the timing right is crucial for probiotic survival. The goal is to get those beneficial bacteria from the bottle to your gut intact. Here’s a breakdown of the best times to take your probiotic:

On an Empty Stomach (Ideally Before Breakfast): Taking a probiotic about 30 minutes before your first meal, typically breakfast, allows the beneficial bacteria to travel to your gut with minimal interference from stomach acid. A glass of water is a great addition!
- Why This Works: When your stomach is empty, the pH is lower, creating a less harsh environment for the probiotic bacteria to survive.
- The Science: A study in Beneficial Microbes found that survival of key bacterial strains improved when taken 30 minutes before a meal.

How to Take a Probiotic for Different Age Groups

The best way to take a probiotic can vary based on age and specific needs. Here’s a breakdown:

Adults: Aim for 30 minutes before a meal on an empty stomach (as mentioned above).
Young Children (Under 3): For infants and toddlers, sprinkle a multi-species probiotic in powdered form (like EndoMune Baby Probiotic Powder) in a liquid, non-carbonated formula, or on soft foods before or with their meal once a day. This helps support their developing immune systems and potentially reduce issues like colic.
Older Children: Once kids are past the toddler stage, they can transition to a chewable probiotic (like EndoMune Kids Advanced Chewable Probiotic) following the general adult guidelines.

Taking Probiotics While on Antibiotics: A Crucial Consideration

Antibiotics are often necessary to combat bacterial infections, but they can also wreak havoc on your gut microbiome by killing off both harmful and beneficial bacteria. If you’re on antibiotics, taking a probiotic is recommended.

The Key to Success: Separate your antibiotic and probiotic doses by at least two hours. This gives the probiotic bacteria a chance to establish themselves without being immediately targeted by the antibiotic.

The Power of Prebiotics: Fueling Your Probiotic

Prebiotics are non-digestible plant fibers and carbohydrates that act as food for the beneficial bacteria in your gut. Think of them as fertilizer for your probiotic!

Look for Probiotics with Prebiotics: Many high-quality probiotics include prebiotics in their formulation. Fructooligosaccharides (FOS), found in foods like garlic, leeks, asparagus, and bananas, are a common and effective prebiotic. (EndoMune products contain FOS)
Dietary Sources: Increase your prebiotic intake through diet by incorporating foods rich in fiber.

Additional Tips for Maximizing Probiotic Effectiveness

Choose the Right Strain: Different probiotic strains offer different benefits. Consider your specific needs when selecting a probiotic supplement. If you are concerned about thrush, consider probiotic strains, like Lactobacillus acidophilus and Bifidobacterium, found in EndoMune Advanced Probiotic and EndoMune Kids products.
Start Slowly: If you’re new to probiotics, start with a lower dose and gradually increase it to avoid digestive discomfort.
Be Consistent: Regular probiotic use is key for maintaining a healthy gut microbiome. Make it part of your daily routine.
Store Properly: Follow the storage instructions on the probiotic label. Some probiotics require refrigeration – EndoMune Advanced Probiotic does not require refrigeration.
Consult Your Doctor: Always talk to your doctor before starting any new supplement, especially if you have underlying health conditions or are taking medications. They can help you choose the right probiotic and dosage for your individual needs and to address any concerns you may have, particularly if you’re taking a drug for a specific health issue, like an immunosuppressant or antifungal.

Mastering the Art of Taking Probiotics

Understanding how to take a probiotic is essential for unlocking its full potential. By following these guidelines, you can optimize your gut health and experience the wide-ranging benefits of these beneficial bacteria. Remember to choose a high-quality probiotic like an EndoMune Advanced Probiotic and be consistent taking them. Lastly, always consult with your doctor to ensure that taking probiotic supplements is the right choice for you.

References:

Saxelin M, Lassig A, Karjalainen H, et al. Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese. Int J Food Microbiol 2010;144(2):293-300. doi:10.1016/j.ijfoodmicro.2010.10.009
Tompkins T, Mainville I, Arcand Y. The impact of meals on a probiotic during transit through a model of the human upper gastrointestinal tract. Beneficial Microbes 2011;2:4:295-303.
Possemiers S, Marzorati M, Verstraete W, et al. Bacteria and chocolate: a successful combination for probiotic delivery. Int J Food Microbiol 2010;141(1-2):97-103. doi:10.1016/j.ijfoodmicro.2010.03.008
Fernández-Alonso M, Aguirre Camorlinga A, Messiah SE, et al. Effect of adding probiotics to an antibiotic intervention on the human gut microbial diversity and composition: A systematic review. J Med Microbiol 2022;71(11):10.1099/jmm.0.001625. doi:10.1099/jmm.0.001625

How to Take a Probiotic: The Ultimate Guide to Boosting Your Gut Health Read More »

Can You Meditate Your Way to Better Gut Health?

Digestive Health, Healthy Aging, Probiotics / By Staff Writer

Can a meditation practice improve the health of your brain… and your gut?

Meditation is one of the best things you can do to support the health of your mind and body. Many people use meditation as a drug-free alternative in a myriad of ways, including reducing stress levels, controlling anxiety, improving concentration and supporting better sleep.

No doubt, investing a few minutes each day in a quiet place away from the world to meditate is a peaceful, mindful way to better health.

But, can you meditate your way to better gut health? Let’s travel across the globe to find out…

Let’s meet some Tibetan monks!

A team of Chinese researchers put the powers of meditation to the test with the help of 37 Tibetan Buddhist monks in a study appearing in BMJ Journals: General Psychiatry.

Scientists analyzed stool and blood samples from those monks who had practiced mediation for an average of 19 years, then compared them to samples taken from a control group of 19 residents in neighboring areas.

None of the patients participating in this trial had taken any antibiotics, antifungal drugs or probiotics that would affect their gut health for the previous three months, and both groups were matched for age, diet, blood pressure and heart rate.

You probably won’t be too surprised to learn that the makeup and volume of bacteria in the guts of monks was very different and much healthier, than those found in the control group.

Although the gut health of the monks wasn’t as diverse, their microbiomes were populated in far higher volumes with beneficial bacteria that reduced incidences of depression and promoted better behaviors.

What’s more, meditation was associated with healthier metabolic functions that are critical in protecting the integrity of the gut barrier and better regulating immune functioning.

You don’t need to move to Tibet to protect your gut health!

Despite the good news about the benefits of meditation for your gut health, scientists acknowledged the geography issue with this study.

Tibetan monks live very, very differently than we do. Their diets comprise a more limited range of foods and they live in higher altitudes away from almost all modern distractions.

There’s no doubt that meditation is a great practice that serves as a springboard to cultivate better mental health, but that probably doesn’t mean you can ignore the health of your gut either.

The safest and best way to protect the health and diversity of your gut — whether you meditate or not — is also the simplest, if you take a probiotic formulated with multiple strains of beneficial bacteria like those found in EndoMune Advanced Probiotic.

Resources

BMJ Journals: General Psychiatry

PsyPost

Healthline

Can You Meditate Your Way to Better Gut Health? Read More »

A Probiotic Solution For Long COVID

Digestive Health, Disease, Probiotics / By Staff Writer

Could taking a multi-species probiotic improve symptoms of Long COVID?

We ask this question because the chances are very good that you know someone who has experienced Long COVID.

More than 25 percent of the 134 million Americans who contracted COVID-19 had experienced symptoms of Long COVID, according to Census Bureau data.

Nearly 10 percent of those patients were still struggling with the very same collection of Long COVID symptoms, including brain fog, extreme fatigue, cognitive challenges, insomnia, depression and gastrointestinal problems.

Some of these Long COVID symptoms are connected to the health of your gut and the depletion of beneficial bacteria.

So, is it possible that a probiotic targeted with specific species of bacteria makes a real difference in treating Long COVID symptoms?

The multi-species advantage

Scientists at the Chinese University of Hong Kong addressed this probiotic possibility in a study that tracked the health of 463 patients experiencing Long COVID symptoms for six months.

A group of 232 patients were treated twice daily with a probiotic formulated with three strains of beneficial bacteria from the Bifidobacterium family along with three prebiotic compounds while a second group received a placebo containing starch and a low dose of vitamin C.

(Bifidobacterium longum and Bifidobacterium bifidum are two of the key building block strains of beneficial bacteria contained in EndoMune Advanced Probiotic.)

Patients completed questionnaires that documented 14 symptoms of Long COVID and provided stool samples before the study began and after it ended.

Among those who received probiotics, a majority of them experienced welcome improvements in their Long COVID symptoms in all categories, highlighted by alleviations in memory loss, concentration problems, fatigue and general unwellness, as well as increases in bacterial diversity.

Planning for the future

With changes coming in the CDC pipeline that would further loosen COVID isolation recommendations to match those for flu and RSV, it’s more important than ever to protect your immune health.

One of the best things you can do to keep your immune system running as it should be is to protect the diversity of bacteria in your gut which means taking a probiotic, ideally with multiple strains of beneficial bacteria like EndoMune.

By the way, fortifying your immune health is only one of many benefits you’ll get by taking a probiotic. Check out our 5 Reasons Why You Need a Probiotic article to get a handle on the many reasons why taking a multi-strain probiotic like EndoMune is good for many more health reasons.

Resources

The Lancet Infectious Diseases

A Probiotic Solution For Long COVID Read More »

Antibiotic-Resistant Bacteria Can Live in Your Body For Years!

Digestive Health, Drug interactions, Probiotics / By Staff Writer

Summary: Did you know some antibiotic-resistant bacteria can live in your body for nearly a decade?

Once upon a time, antibiotics were considered miracle drugs used to treat serious health problems and control the spread of once-fatal diseases.

However, we have learned over time that antibiotics worked almost too well.

Patients and their physicians came to rely on them so often for common health problems — from colds to sinus infections — that they can stop working altogether, creating problems with resistance to common antibiotics like those derived from penicillin or cephalosporin.

When those antibiotic-resistant superbugs take over your body they could hang around for nearly 10 years, based on the findings of a recent study appearing in Nature Communications.

Antibiotic-resistant bacteria hang on for a long time!

European researchers tracked the presence of two strains of antibiotic-resistant bacteria (E. coli and K. pneumoniae) in 73 patients every time they were admitted to their hospital from 2008 to 2018.

More than 350 samples of drug-resistant bacteria were collected during that time. Most of those bacteria were discovered as part of routine hospital screenings, but 12.5 percent were detected because the patient was a suspected carrier of an infection.

Depending on the strain, these resistant bacteria could live in various areas of the human body for nearly five years (K. pneumoniae) or more than nine years (E. coli). But that’s not all…

“These patients not only repeatedly become ill themselves, they also act as a source of infection for other people, a reservoir for these pathogens,” says Dr. Lisandra Aguilar-Bultet, the study’s lead author and a research associate in microbial genomics and bioinformatics at Switzerland’s University Hospital of Basel.

What this means for you

Before you begin to panic, know this: Bacteria like E. Coli live in your intestines, and most strains do little to no harm, according to the Mayo Clinic. But there are some that can do harm, as shown in this study.

The good news: You can do a lot to lessen your need for antibiotics merely by following our simple-to-follow antibiotic protocol.

But there will be times that you will need to take an antibiotic for a health problem.

When you absolutely need to take an antibiotic, protect the healthy balance of bacteria in your gut — the center of your body’s immune system — by taking a probiotic, ideally with multiple strains of beneficial bacteria, like those found in EndoMune Advanced Probiotic.

Taking a probiotic like EndoMune about two hours before your prescribed antibiotic gives those beneficial bacteria a jump on reaching your gut and protecting it and you from harmful superbugs.

References

Nature Communications

University of Basel

LiveScience

Mayo Clinic

Antibiotic-Resistant Bacteria Can Live in Your Body For Years! Read More »