Probiotics Archives

Bloating: Can We Talk About Gas?

Digestive Health, Probiotics / By Staff Writer

Bloating (Intestinal gas) is a very common problem in the general population and is a frequent reason why people seek medical attention. Passage of intestinal gas is viewed differently depending your age and gender.

Kids make lots of jokes and take pride in telling someone to “pull my finger.” Boys grow up to be men who believe passing flatus is not rude or embarrassing and like to use phrases like “whoever smelt it dealt it” or “whoever denied it supplied it.”

Females would like to deny that intestinal gas exists and will try to hold it to avoid any embarrassment. This practice can certainly lead to increased intestinal symptoms of bloating, distention, and discomfort.

One of the most common symptoms leading individuals to seek gastrointestinal evaluation is “gas.” They are convinced that excess gas is the cause of their abdominal bloating and distention. In addition, they believe that the need to belch and expel flatus is also due to an excess production of gas.

There have been many studies evaluating the above mentioned symptoms and results are rather surprising.

BELCHING

Belching is due to swallowing excess air. It is not due to increased intestinal or gastric production.

We all swallow some air when we eat or drink especially carbonated beverages. But people who complain of needing to belch frequently usually have developed an air-swallowing habit. This usually occurs for one of two reasons:

Sometimes people swallow excess air to ease symptoms due to heartburn or ulcers. Easing these symptoms with acid suppressive medications may lessen the desire to swallow air.
The other reason for chronic belching is due to an unconscious way of dealing with stress or anxiety. For these individuals, making them aware of their excess air swallowing can sometimes be helpful.

BLOATING AND DISTENTION

When people experience the discomfort of abdominal bloating and distention, they believe it is due to excess gas production in the intestines.

Studies have determined that people who have symptoms of bloating have no more intestinal gas than normal people¹. The cause of the symptoms has been attributed to “visceral hypersensitivity.”

Visceral hypersensitivity is a term used to describe the heightened level of intestinal discomfort that individuals experience due to normal intestinal activity.

Research studies have found that when air is instilled into the intestines of individuals with visceral hypersensitivity, they experience symptoms of bloating and distention while the normal group notices no discomfort.²

Visceral hypersensitivity has been thought to be part of the syndrome of Irritable Bowel Syndrome(IBS). Historically, this syndrome has been attributed to psychological disorders. However, recent observations have noted that up to 30% of individuals who experience an episode of infectious diarrhea develop post infectious IBS symptoms³. One of the most prominent symptoms of IBS is bloating.

The current thinking is that an intestinal infection disrupts the healthy intestinal bacterial flora resulting in an immune response that leads to chronic low-grade inflammation. The inflammation then causes visceral hypersensitivity.

Recent studies using probiotics to re-establish the normal intestinal bacterial flora have been successful in down regulating the inflammation and easing the symptoms of bloating.^4,5

FLATULENCE

Here are some interesting facts you can share with your friends, about flatulence:

Passage of gas or flatus is normal. Generally, healthy people pass 8-25 ounces daily. Frequency is 10-20 passages/day.

Gas is produced by intestinal bacteria primarily located in the colon.

The amount gas produced is determined by three factors:

The amount and type of carbohydrates consumed
The amount and types of intestinal bacteria present
The ability of the small intestines to digest and absorb the carbohydrates

Two common causes of excess flatulence are:

poor digestion of the sugar lactose in dairy products;
limited absorption of fructose which is a sugar found in soft drinks and certain fruits like apples and bananas.

Some vegetables have starches that are only partially absorbed. The nonabsorbed starches pass into the colon and contribute to excess flatus production. Beans, brussel sprouts, carrots, onions and celery are the major offenders.

The carbohydrates in bread and pasta can be a problem for some people. Recently, there has been a lot written about “gluten sensitivity.” Avoiding the grains of wheat, barley, and rye can help some people lessen the production of excess flatus.

Colonic bacteria normally generate intestinal gas through fermentation of the carbohydrates that escaped absorption in the small intestines. An imbalance in the gut bacterial flora may result in excessive gas formation. Some bacterial groups are more prone to gas production than others. Hence, improving the bacterial balance with a probiotic may improve gas-related symptoms.⁸

Take Home Message

If you are experiencing symptoms of bloating, distention, or increased flatus, consider taking a high quality probiotic like EndoMune.

In addition, you may want to modify your diet by avoiding foods that contribute to flatulence. It is always wise to check with your doctor if your symptoms persist.

Eat healthy, exercise and live well!!!

Best Wishes,

Dr. Hoberman

Foods that may cause gas include:*

Beans
Vegetables, such as broccoli, cabbage, brussels sprouts, onions, artichokes, and asparagus
Fruits, such as pears, apples, bananas and peaches
Whole grains, such as whole wheat and bran
Soft drinks and fruit drinks
Milk and milk products, such as cheese and ice cream, and packaged foods prepared with lactose, such as bread, cereal, and salad dressing
Foods containing sorbitol, such as dietetic foods and sugar-free candies and gums

References

*National Digestive Diseases Information Clearinghouse
Gas in the Digestive Tract

http://digestive.niddk.nih.gov/ddiseases/pubs/gas/

1) An understanding of excessive intestinal gas.
Suarez FL, Levitt MD.Curr Gastroenterol Rep. 2000 Oct;2(5):413-9. Review.

2) J Gastroenterol Hepatol. 2011 Apr;26 Suppl 3:119-21. doi: 10.1111/j.1440-1746.2011.06640.x.Visceral hypersensitivity in irritable bowel syndrome.
Kanazawa M, Hongo M, Fukudo S

3) Incidence of post-infectious irritable bowel syndrome and functional intestinal disorders following a water-borne viral gastroenteritis outbreak.Zanini B, Ricci C, Bandera F, Caselani F, Magni A, Laronga AM, Lanzini A; San Felice del Benaco Study Investigators.Am J Gastroenterol. 2012 Jun;107(6):891-9. doi: 10.1038/ajg.2012.102. Epub 2012 Apr 24.

4) The putative role of the intestinal microbiota in the irritable bowel syndrome.
Collins SM, Denou E, Verdu EF, Bercik P.Dig Liver Dis. 2009 Dec;41(12):850-3

5) Probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders: a double-blind study.
Ringel-Kulka T, Palsson OS, Maier D, Carroll I, Galanko JA, Leyer G, Ringel Y.
J Clin Gastroenterol. 2011 Jul;45(6):518-25.

6) Non-Celiac Wheat Sensitivity Diagnosed by Double-Blind Placebo-Controlled Challenge: Exploring a New Clinical Entity.Carroccio A, Mansueto P, Iacono G, Soresi M, D’Alcamo A, Cavataio F, Brusca I, Florena AM, Ambrosiano G, Seidita A, Pirrone G, Rini GB.Am J Gastroenterol. 2012 Jul 24. doi: 10.1038/ajg.2012.236.

7) Review article: the treatment of functional abdominal bloating and distension.Schmulson M, Chang L.Aliment Pharmacol Ther. 2011 May;33(10):1071-86. doi: 10.1111/j.1365-2036.2011.04637.x. Epub 2011 Mar 29. Review.

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Get a Probiotic Radiation Shield for Your Gut

Disease, Probiotics / By Staff Writer

Cancer and its treatments take a toll on the human body. One of the most common methods of cancer treatment, radiation, indiscriminately destroy both malignant and healthy cells potentially creating its own host of long-term health problems. However, new studies with lab mice out of St. Louis, Missouri’s Washington University School of Medicine have found that radiation therapy patients who take probiotics prior to receiving radiation cancer treatment therapy may gain intestinal radio-protective benefits.

Astoundingly, the study’s implications reach even further than cancer patients additionally detailing potential probiotic benefits for all individual hoping to protect themselves from general radiation or at-risk for radiation contamination.

Learn more about this study’s conclusions on the benefits of probiotics by reading the full article from NaturalNews.com

Get a Probiotic Radiation Shield for Your Gut Read More »

Probiotic-Assisted Antibiotic Diarrhea Prevention

Disease, Probiotics / By Staff Writer

Probiotics have a proven effect on children with antibiotic-induced diarrhea and acute infectious diarrhea. So it stands to reason that probiotics also help adults avoid these conditions. Recently, a study was released that inconclusively implied that probiotics had a positive effect on regulating and preventing adult antibiotic diarrhea. Results leaned toward the positive, but the presence of unexplained heterogeneity in the study’s results gives support for further analysis and examination.

For full details on the results of this probiotic study, please check out the full article, here.

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Probiotics – Helping You Think Happy Thoughts?

Mental Health, Probiotics / By Staff Writer

A recent study analyzing the effect of gut bacteria and probiotics on brain activity may have positive implications for individuals. Although still in the most preliminary stages of analysis and evaluation, scientists have discerned a link between the presence of probiotics in the diet and muted mental reactions to outside negative stress or stimuli.

Read the full article for details on how the study was conducted and when these hypotheses may gain enough support to become proven facts.

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Probiotics in the Medical News

Drug interactions, Probiotics / By Staff Writer

Endomune Subscriber,

I am amazed by the number of new medical articles on probiotics. The scientific evidence of probiotic benefits keeps expanding.

In May 2012, two major medical journals published reports about the advantages of probiotics.

Why take a probiotic when prescribed an antibiotic?

A 53-year-old woman reports severe watery diarrhea with cramps. She is in her seventh day of a 10-day course of cefixime, which was prescribed for bronchitis.

Could the diarrhea have been prevented?

In the May 9th issue of Journal of the American Medical Association (JAMA), there was a report titled “Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea”(AAD).

When antibiotics are prescribed for infections like bronchitis, they can also destroy the healthy intestinal bacteria in the body. As a result, harmful bacteria can proliferate and cause diarrhea that ranges from mild to life-threatening.

The study reviewed 82 trials in which patients (adults and children) randomly received either an antibiotic alone or in combination with a probiotic.

A total of 11,811 studied patients were pooled together for the reviewed trials. The authors found that adding a probiotic when prescribing an antibiotic reduced the risk for diarrhea by 42%.

Take away message

Based on the results of this report, ask your health care provider if he/she would recommend a probiotic when prescribed an antibiotic. Remember to separate the time of taking an antibiotic and the probiotic by two hours. This will lower the risk of the antibiotic destroying the probiotic bacteria.

Can probiotics prevent urinary tract infections?

A 64-year old woman is on her third course of antibiotics for recurrent urinary tract infections. Unfortunately, the cultured E. coli bacteria are resistant to the antibiotic medication.

Was there anything else she could have tried?

In the May 14th issue of the Archives of Internal Medicine, a clinical trial² was published titled “Lactobacilli vs Antibiotics to Prevent Urinary Tract Infections.”

Recurring UTIs are common among some women and low-dose antibiotics can sometimes prevent them. The worry is that overuse of the drugs also reduces their effectiveness by making disease-causing bacteria like E. coli resistant.

The authors conducted a controlled trial in 252 postmenopausal women with recurrent UTIs.

The randomized patients would receive a daily antibiotic or a probiotic containing Lactobacilli for one year.

The researchers then tracked how many UTIs occurred in each group of women over a year. They also collected vaginal swabs and samples of the women’s urine and feces every month to test for the presence of good bacteria and infection-causing bacteria like E. coli.

Over the year, the antibiotic group had an average of 2.9 UTIs per woman, and the probiotic group had an average of 3.3 UTIs. In the year prior to the study, the average number of recurrent UTIs was 7 in each group.

About 20 percent to 40 percent of E. coli in samples from all the women resisted the antibiotic at the beginning of the study. At 12 months between 80 percent and 95 percent of the bacteria resisted the drug in the women taking the antibiotic.

The resistance rate of the E. coli in the women taking the probiotic was slightly lower at one year compared to the start of the study. That is, the E. coli did not develop antibiotic resistance.

The authors concluded that taking a daily antibiotic was not any better than taking a probiotic in lessening recurrent rate of UTIs. “However, the development of antibiotic resistance is considerably lower with the use of lactobacillus. Therefore, lactobacilli may be an acceptable alternative for prevention of UTIs, especially in women who dislike taking antibiotics.”

Take away message

If you have recurrent UTIs, consider taking a probiotic containing Lactobacillus…like EndoMune.

Eat healthy, exercise, take EndoMune and live well!

Dr. Hoberman

1) Hempel,S PhD; Newberry,S PhD; Maher,A, MD; et al. Probiotics for the Prevention and Treatment of Antibiotic-Associated DiarrheaA Systematic Review and Meta-analysis JAMA. 2012;307(18):1959-1969. doi:10.1001/jama.2012.3507

2) Beerepoot MAJ, ter Riet G, Nys S, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172(9):ioi120011704-712

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Probiotics, Leaky Gut and Autoimmune Diseases

Disease, Drug interactions, Probiotics / By Staff Writer

I am hopeful you all had a wonderful holiday season and will enjoy a healthy and successful New Year.

January is the month in which we make resolutions to exercise, eat healthy and maybe lose a few of those unwanted pounds.

This month’s newsletter discusses another reason why you should consider adding EndoMune to your list of healthy things to do.

Leaky Gut Makes Way for Harmful Toxins

I want to begin 2012 by sharing with you an important probiotic benefit that I haven’t previously mentioned. The term “leaky gut” has been around for a long time. It has been used more in the alternative medicine sector to explain a variety of health issues⁽²⁾.

Conventional medicine now recognizes the importance of a healthy intestinal barrier against toxins and harmful intestinal organisms. When there is a breakdown in this barrier, the disorder is decsribed as “increased intestinal permeability”⁽³⁾ – or, in other words, leaky gut.

In the November issue of the medical journal, Clinical Reviews in Allergy and Immunology, Dr. Alessio Fasano (Director of the University of Maryland Center for Celiac Research) published an article on “Leaky Gut and Autoimmune Diseases”⁽⁴⁾.

As a pediatric gastroenterologist and research scientist, he has developed a theory on how a leaky gut can contribute to autoimmune disorders such as:

Celiac disease
Inflammatory bowel disease
Type 1 diabetes
Multiple sclerosis
Rheumatoid arthritis

Evolution of a Healthy Intestinal Barrier

As man evolved, it was critical to develop a mechanism that would allow humans to coexist with intestinal organisms like bacteria and parasites. Some of the organisms were beneficial but others could invade and cause serious infections and death.

Fortunately, the intestinal lining cells acts as an effective barrier between the internal and external environment. From a physical standpoint, the lining is similar to a brick wall. The bricks are the intestinal cells and the mortar is the “tight junction” between the cells. The tight junction is made up of secreted proteins that make the lining impermeable to some of the gut contents. The healthy intestinal bacteria – like those in probiotics – help maintain the intestinal barrier by stimulating the production of tight junction proteins.

One of the major proteins in the tight junction is called zonulin. “Zonulin works like the traffic conductor or the gatekeeper of our body’s tissues. Zonulin opens the spaces between cells allowing some substances to pass through while keeping harmful bacteria and toxins out⁽⁵⁾,” explains Dr. Fasano. “It has a major effect on intestinal permeability.

Zonulin: A Contributor to Autoimmune Diseases

Studies suggest that increased levels of zonulin are a contributing factor to the development of autoimmune diseases. Zonulin weakens the other proteins making up the tight junction resulting in increased intestinal permeability.

In individuals with a genetic predisposition to autoimmune disorders, a leaky gut exposes their immune cells to proteins in bacteria, viruses and other environmental agents. They then develop antibodies which cross react to their own cells resulting in a variety of autoimmune diseases.

Dr. Fasano performed a clinical trial in patients with celiac disease. This disorder is due to an immune reaction against gluten proteins in grains. The studies found that when individuals with a genetic predisposition to celiac disease were challenged with gluten, there was a 70% increase in intestinal permeability and an increase in zonulin. By giving a drug that blocks the activity of zonulin, however, there was no increase in permeability when exposed to gluten. Additionally, the patients didn’t develop diarrhea or symptoms associated with celiac disease.

When the healthy intestinal balance is disturbed by such diverse things as repeated antibiotic exposure, stress or alcohol misuse, the harmful bacteria are then able to penetrate the tight junctions and invade the wall of the intestines. The result is increased permeability and immune inflammation.

There are a number of studies on how probiotic bacteria stimulate the production of tight junction proteins and prevent increased intestinal permeability^(6,7,8).

This is a very exciting time in intestinal permeability research and understanding how to lessen the risk of developing an autoimmune disease.

I am amazed how intestinal bacteria and specifically probiotic bacteria have such an impact on our overall health!

Take Home Message

If you or any of your family members suffer with an autoimmune disorder, check with your doctor about the benefits of taking a probiotic like EndoMune.

Eat healthy, exercise, take EndoMune and live well!

Best Wishes,
Dr. Hoberman

References

(1) Developmental biology of gut-probiotic interaction Ravi Mangal Patel, Patricia W Lin Gut Microbes. 2010 May-Jun; 1(3): 186–195. Published online 2010 May 26. doi:

(2) A brief evidence-based review of two gastrointestinal illnesses: irritable bowel and leaky gut syndromes. Kiefer D, Ali-Akbarian L. Altern Ther Health Med. 2004 May-Jun; 10(3):22-30; quiz 31, 92.

(3) Intestinal permeability, leaky gut, and intestinal disorders. Hollander D. Curr Gastroenterol Rep. 1999 Oct; 1(5):410-6.

(4) Leaky Gut and Autoimmune Diseases. Fasano A.Clin Rev Allergy Immunol. 2011 Nov 23.

(5) Physiological, Pathological, and Therapeutic Implications of Zonulin-Mediated Intestinal Barrier Modulation : Living Life on the Edge of the WallAlessio Fasano Am J Pathol. 2008 November; 173(5): 1243–1252

(6) Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics.Sartor RB Gastroenterology. 2004 May ;126(6):1620

(7) VSL#3 probiotics regulate the intestinal epithelial barrier in vivo and in vitro via the p38 and ERK signaling pathways.Dai C, Zhao DH, Jiang M.Int J Mol Med. 2012 Feb;29(2):202-8. doi: 10.3892/ijmm.2011.839. Epub 2011 Nov 15.

(8) Molecular regulation of the intestinal epithelial barrier: implication in human diseases.Liu Z, Shi C, Yang J, Zhang P, Ma Y, Wang F, Qin H.Front Biosci. 2011 Jun 1;17:2903-9. Review.

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Yale Workshop on Probiotics Presents New Research

Drug interactions, Probiotics / By Staff Writer

I just returned from the 3rd Yale Workshop on “Advances in Probiotic Use” and am pleased to report there is a large amount of active research in the area of the intestinal bacteria. Namely, research is examining how bacteria impact human health and disease.

Among various findings, researchers presented new information about how probiotic bacteria can modulate the intestinal immune system. They have discovered how probiotic bacteria interact with the intestinal lining cells to improve the inflammatory conditions that occur due to infection colitis and ulcerative colitis.

In addition, there were a number of discussions about how the healthy intestinal bacteria can break down or ferment indigestible dietary starches. The breakdown products (short chain fatty acids) enhance the intestinal function, improve intestinal motility and lessen the risk of colon cancer. This is called a symbiotic relationship – mutually beneficial for the human host and the bacteria.

The conclusions from the various presentations are that probiotics can:

Lessen irritable bowel syndrome symptoms
Shorten the duration of infectious diarrhea in children
Aid in the prevention of antibiotic-associated diarrhea
Aid in the management of ulcerative colitis
Aid in the prevention of childhood allergies like eczema

Transplantation Therapy to Improve Bacteria Balance

An infection with a bacterium called Clostridia difficile can cause life-threatening colitis. The infection occurs when the healthy intestinal bacteria are reduced as a result of taking an antibiotic for something like a sinus infection.

There are special antibiotics that can destroy the Clostridia difficile infection. Unfortunately, there is a tendency for the infection to recur multiple times in the same person despite taking appropriate antibiotics to kill the Clostridia difficile organisms.

In an attempt to treat Clostridia difficile, a new innovative form of therapy was also discussed. The therapy involves the transplantation of stool from healthy individuals into patients as a means to re-establish a healthy intestinal bacterial balance.

There have been a few published case reports dating back to 1958 of transplanting healthy stool into patients who had recurrent Clostridia infections, and the results were very promising. Larger trials of infusing suspensions of healthy stool into ill patients have been recently done. The results have shown a cure rate of more than 90% within two days!!

This presentation was very thought provoking. To have this type of cure rate certainly indicates the importance of the healthy intestinal bacteria. The procedure is aesthetically unpleasing, but the alternative is to give the healthy bacteria in capsule form – accomplished when probiotics are prescribed.

Take Home Message

All of the presentations at the Yale Workshop provide further evidence of the importance of a healthy balance of intestinal bacteria. In addition, the studies confirm that probiotic bacteria have many beneficial benefits in helping to improve and maintain normal intestinal immune and digestive functions.

Please consider taking a high quality probiotic like EndoMune if you are going to take antibiotics or if you are struggling with ongoing GI symptoms despite medical evaluation.

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Probiotics Recommended for Nursing Home Residents

Healthy Aging, Mental Health, Probiotics / By Staff Writer

Over the years, I have written a number of newsletters that discuss the benefits of probiotics for children and adults. This month will focus on the older generation, an important topic since there are currently 11.4 million people living in nursing homes in the United States ⁽¹⁾. This figure includes 14% of the population older than 84.

For anyone who has loved ones in nursing homes and is concerned for their well-being, there are numerous reasons I recommend all nursing home patients take probiotics.

Scenario One: Hospitalization

A recurring story is that of a functioning senior citizen living at home who fractures a hip due to a fall or experiences a stroke. The following series of events is likely to happen:

Upon injury, 9-1-1 is called.
The individual becomes a hospitalized patient.
The patient is required to take medications, including antibiotics.
The antibiotics adversely affect the gastrointestinal tract.
The individual is now at risk of developing hospital-acquired infections like Clostridia difficile and methicillin-resistant staph infections.
Eventually, the patient improves and is transferred to a rehab unit or nursing home.

The seniors may have had normal intestinal function prior to hospitalization, but with all the medications and change in activity level, constipation and diarrhea become real problems. These disorders can severely affect quality life and health of the people within the nursing homes.

For instance, other healthy nursing home residents are now at risk of being exposed to surface areas that have become contaminated by the arrival of the recently hospitalized patients.

This scenario is one reason to consider giving probiotics to healthy nursing home residents. Should a resident be exposed, the probiotics can prevent harmful bacteria from colonizing the intestines and causing damage.

Scenario Two: General Aging Process

Another main reason to give probiotics has to do with the changes that occur in the normal intestines as they age. Due to reduction in acid production, enzyme secretions, reduced intestinal immunity and slowed motility, the healthy intestinal bacteria population is reduced. This change in the intestinal microflora contributes to the risk of diarrhea and constipation.

According to the Administration of Aging ⁽²⁾, among healthy adults 65 years of age and older, 26% of men and 34% of women experience constipation. These numbers increase drastically for elderly people living in nursing homes – more than 80% suffer from constipation. Medications, immobility, and dementia are all contributing factors for this increase.

Residents of nursing homes have a much higher risk of developing infectious diarrhea. In the United States, nursing home residents are four times more likely to die from gastroenteritis than those living outside nursing homes. Additionally, of all deaths occuring from diarrheal disease, nursing home residents account for 17.5% ^(3,4).

The physicians and nursing staff are very aware of the health risks associated with severe constipation and diarrhea. Unfortunately, nursing home patients often require medications that can slow intestinal motility, damage the lining cells, and disrupt the healthy balance of the intestinal bacteria. As a result, severe intestinal disorders can occur despite good medical care.

Probiotics Improve Constipation and Diarrhea

During the last three years, there have been several reports published that found that probiotics improved constipation and diarrhea in nursing home residents ^(5,6,7). The research protocols were similar; One group of residents received probiotics containing Lactobacillus and/or Bifidobacteria, and the other group received a placebo. The research findings revealed that the frequency and consistency of the stools improved in the groups treated with probiotics, as compared to the control groups ^(5,6,7).

After considerable review of the literature, I have come to the conclusion that giving nursing home residents daily probiotics can help to improve intestinal function, quality of life, and lessen the risk of serious health issues.

The real concern in medicine is that we “do no harm.” Probiotics, fortunately, have an excellent safety profile. It is worth noting, though, that there have been rare reports of infections due to probiotics in seriously immune-compromised patients ⁽⁹⁾.

Take Home Message

If you have a loved one in a nursing home, ask the health care provider to consider giving them a probiotic. The daily dosage should be at least 10 billion and contain multiple strains of Lactobacillus and Bifidobacteria, like EndoMune Advanced.

Eat healthy, exercise and live well!
Dr. Hoberman

References:

(1) National Center for Health Statistics. Health, United States, 2009: with special feature on
medical technology. Hyattsville, MD, 2010.

(2) Sources: Data releases from the web sites of the National Center for Health Statistics; and from the Bureau of Labor Statistics web site

(3) Mortality due to gastroenteritis of unknown etiology in the United States. Frenzen PD.J Infect Dis. 2003 Feb 1;187⁽³⁾:441-52. Epub 2003 Jan 24

(4) Clin Infect Dis. 2010 Oct 15;51⁽⁸⁾:907-14.Surveillance for outbreaks of gastroenteritis in long-term care facilities, Australia, 2002-2008. Kirk MD, Fullerton KE, Hall GV, Gregory J, Stafford R, Veitch MG, Becker N

(5) Efficacy of Lactic Acid Bacteria (LAB) supplement in management of constipation among nursing home residents. 1)Sources: Data releases from the web sites of the National Center for Health Statistics; and from the Bureau of Labor Statistics web site

(6) Fermented cereal with specific bifidobacteria normalizes bowel movements in elderly nursing home residents. A randomized, controlled trial.Pitkala KH, Strandberg TE, Finne Soveri UH, Ouwehand AC, Poussa T, Salminen S.J Nutr Health Aging. 2007 Jul-Aug;11(4):305-11

(7) Clostridium difficile in the long-term care setting. Makris AT, Gelone S.J Am Med Dir Assoc. 2007 Jun;8⁽⁵⁾:290-9. Review

(8) Probiotics and the nursing home: should we give bacteria for breakfast?Morley JE.J Am Med Dir Assoc. 2009 Jul;10⁽⁶⁾:365-7.

(9) Safety assessment of probiotics for human use.Sanders ME, Akkermans LM, Haller D, Hammerman C, Heimbach J, Hörmannsperger G, Huys G, Levy DD, Lutgendorff F, Mack D, Phothirath P, Solano-Aguilar G, Vaughan E.Gut Microbes. 2010 May;1⁽³⁾:164-185. Epub 2010 Mar 4.

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Are Bugs in the Gut Good for Your Skin

Diet, Drug interactions, Probiotics / By Staff Writer

Over the years, I have reviewed many of the diverse health benefits of probiotics, and the list keeps getting longer.

Probiotics have been shown to lessen the risk of:

Irritable Bowel Syndrome symptoms
Infectious diarrhea
Antibiotic related diarrhea
Vaginal yeast infections
Recurrent female urinary tract infections
Cold and flu illness symptoms in children
Allergy related disorders like eczema
Colon cancer

Most of the benefits of probiotics are related to their direct effects in the intestines, but there are extra-intestinal benefits.

For example, the probiotic bacteria can stimulate the intestinal immune cells to release substances into the blood stream that will then strengthen the immune cell functions in the upper respiratory tract. The result is to lessen the flu and cold symptoms of cough, runny nose and fever.

So how does taking a probiotic orally have a benefit for our skin? It has to do with modifying the reactions of the immune cells in the skin.

Numerous recent human clinical trials involving the immune system have found that probiotic supplementation might be useful in the management of skin allergies like eczema and dry skin ^(1,2,3).

Protective Function of Probiotics

There are several recent studies that have demonstrated that UV exposure induces dramatic changes in the skin’s immune functions^(4,5), and how probiotics may be protective.

Part of the aging process of the skin is related to our frequent exposure to UV radiation, which causes inflammation. The result is damage to skin collagen and cell DNA. We all know that repeated sun exposure increases the risk for wrinkles and skin cancer.

To determine if probiotics could modify the skin’s immune reaction to UV exposure, 54 volunteers were randomized in two groups (27 each group) taking a placebo or a probiotic for 8 weeks before UV exposure⁽⁶⁾. Biopsies of the skin were taken to determine the effects of the probiotic versus the placebo on the immune reaction of the skin.

The results found that the probiotic could modulate the immune reaction and lessen the inflammatory damage. The authors of the study concluded that probiotics may “represent a new strategy for photoprotection.”

There are even studies looking at a topical cream containing probiotics. A recent clinical trial demonstrated that the bacterial extracts of cultured probiotics regulated skin reactivity and dryness in healthy female volunteers⁽⁷⁾. So far these are clinical studies; there are no commercial preparations available.

The point is, though, that there is very exciting new research into how the intestinal bacteria can affect our overall health…even the skin!

I am often asked if it is worthwhile taking a probiotic daily. Several years ago I said to take them only if you have some intestinal problems, or if you are taking an antibiotic. Today, I truly believe probiotics should be considered a daily healthy supplement.

Take Home Message

If you are going on an outdoor outing, make sure you use sunscreen and take a good probiotic like EndoMune.

Eat healthy, exercise and live well!
Dr. Hoberman

(1) Probiotics and down-regulation of the allergic response. Kalliomäki MA, Isolauri E.Immunol Allergy Clin North Am. 2004 Nov;24(4):739-52

(2) The development of gut immune responses and gut microbiota: effects of probiotics in prevention and treatment of allergic disease.Rautava S, Isolauri E Curr Issues Intest Microbiol. 2002 Mar;3(1):15-22.

(3) Probiotics during the first 7 years of life: a cumulative risk reduction of eczema in a randomized, placebo-controlled trial.Kalliomäki M, Salminen S, Poussa T, Isolauri E.J Allergy Clin Immunol. 2007 Apr;119(4):1019-21. Epub 2007 Feb 7.

(4) Sunlight and skin cancer: lessons from the immune system.Ullrich SE. Mol Carcinog. 2007 Aug;46(8):629-33. Review

(5) Alterations in human epidermal Langerhans cells by ultraviolet radiation: quantitativeand morphological study.Seité S, Zucchi H, Moyal D, Tison S, Compan D, Christiaens F, Gueniche A, Fourtanier A.Br J Dermatol. 2003 Feb;148(2):291-9

(6) Probiotics for photoprotection.Guéniche A, Philippe D, Bastien P, Blum S, Buyukpamukcu E, Castiel-Higounenc I.Dermatoendocrinol. 2009 Sep;1(5):275-9

(7) Bifidobacterium longum lysate, a new ingredient for reactive skin.
Guéniche A, Bastien P, Ovigne JM, Kermici M, Courchay G, Chevalier V, Breton L, Castiel-Higounenc I.Exp Dermatol. 2010 Aug;19(8):e1-8

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IBS Sufferers Not at Greater Risk for Colon Cancer

Disease, Drug interactions, Probiotics / By Staff Writer

Some very reassuring news was just released from a recent research study. The study, published in the American Journal of Gastroenterology found Irritable Bowel Syndrome (IBS) patients to be at no greater risk than healthy patients for polyps, colon cancer or inflammatory bowel disease.

According to the article:

This research shows that it is unnecessary to order colonoscopies for patients with IBS, unless they show alarming symptoms like unexplained weight loss or anaemia, bleeding from the GI tract, or have a family history of colon cancer, inflammatory bowel disease, or celiac disease, says Dr. Chey.

If you’re interested in reading the article in its entirety on DocGuide.com, visit:
http://www.docguide.com/news/content.nsf/news/852576140048867C852576E20000C862

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