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Dietary changes may affect your gut health, triggering auto-inflammatory bone disease

As you know, the diversity of bacteria in your gut—specifically the lack of it—can be an indicator of serious health conditions, including cardiovascular disease, colon cancer and obesity.

Moreover, your daily diet plays an important role in the makeup of your gut bacteria, which influences your susceptibility to health problems like auto-inflammatory bone disease, according to a study recently published in Nature.

Scientists at St. Jude’s Children’s Research Hospital studied mice with chronic recurrent multifocal osteomyelitis (CRMO), an inflammatory childhood bone disorder. These test animals had mutated Pstpip2 genes whose presence leads to osteomyelitis (an infection inside a bone).

During their research, scientists discovered changing the nutritional balance of test animals affected the makeup of their gut bacteria positively and negatively. Among the bacteria affected by diet variations was Prevotella, which has been linked to inflammatory problems in humans like arthritis, periodontal disease and osteomyelitis.

For example, one beneficial diet scientists tested limited the growth of Prevotella by reducing amounts of Interleukin-1 beta chemicals. (For this study, the supply of Interleukin-1 beta chemical was affected in specific immune cells called neutrophils, chemicals that are the biggest type of white blood cells in mammals that form an essential part of the innate immune system.)

“While multiple lines of evidence have suggested that diet can impact human disease, the scientific mechanism involved was a mystery,” said Dr. Thirumala-Devi Kanneganti of St. Jude’s Department of Immunology.

“Our results show that diet can influence immune-mediated disorders by shaping the composition of the gut microbiome, which our findings suggest play a role in immune regulation.”

The intestinal connection between osteomyelitis and the gut microbiome was verified when scientists successfully treated test mice fed a disease-promoting diet, first, with an array of broad-spectrum antibiotics, then, by transplanting the microbiomes of healthy mice to sicker, genetically modified mice.

“The results suggest probiotics might provide a more targeted method for suppressing production of [Interleukin-1 beta] and protecting against autoimmune diseases,” said Dr. John Lukens, according to a press release.

Often, our go-go-go lifestyles don’t leave us much time to eat healthy, nutrient-rich diets that promote good gut health and boost our collective immune systems.

That’s why taking a probiotic like EndoMune Advanced Probiotic or EndoMune Advanced Junior (for kids) with multiple strains of beneficial bacteria, is so important and beneficial in protecting your health naturally.

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